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Last Updated: May 19, 2022

CLINICAL TRIALS PROFILE FOR XPOVIO


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All Clinical Trials for Xpovio

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01607905 ↗ Safety Study of KPT-330 (Selinexor) in Patients With Advanced or Metastatic Solid Tumor Cancer Completed Karyopharm Therapeutics Inc Phase 1 2012-06-18 Phase 1 study to evaluate the safety and tolerability of selinexor and determine the Recommended Phase 2 Dose (RP2D) of selinexor for advanced or metastatic solid tumor malignancies.
NCT01607905 ↗ Safety Study of KPT-330 (Selinexor) in Patients With Advanced or Metastatic Solid Tumor Cancer Completed Karyopharm Therapeutics, Inc Phase 1 2012-06-18 Phase 1 study to evaluate the safety and tolerability of selinexor and determine the Recommended Phase 2 Dose (RP2D) of selinexor for advanced or metastatic solid tumor malignancies.
NCT02025985 ↗ Study of KPT-330 (Selinexor) in Female Patients With Advanced Gynaecologic Malignancies Completed Karyopharm Therapeutics Inc Phase 2 2014-04-09 The primary trial objective is to determine the efficacy of KPT-330 (selinexor) in participants with advanced or metastatic gynaecological cancers by disease control rate (complete response (CR) or partial response (PR) or stable disease (SD) for at least 12 weeks, assessed according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1.
NCT02025985 ↗ Study of KPT-330 (Selinexor) in Female Patients With Advanced Gynaecologic Malignancies Completed Karyopharm Therapeutics, Inc Phase 2 2014-04-09 The primary trial objective is to determine the efficacy of KPT-330 (selinexor) in participants with advanced or metastatic gynaecological cancers by disease control rate (complete response (CR) or partial response (PR) or stable disease (SD) for at least 12 weeks, assessed according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1.
NCT02178436 ↗ Gemcitabine, Nab-paclitaxel and KPT-330 in Advanced Pancreatic Cancer Recruiting National Cancer Institute (NCI) Phase 1/Phase 2 2014-10-31 This partially randomized phase Ib/II trial studies the side effects and best dose of selinexor when given together with gemcitabine and nab-paclitaxel, and to see how well they work in treating patients with pancreatic cancer that has spread to other parts of the body (metastatic). Drugs used in chemotherapy, such as selinexor, gemcitabine and nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Xpovio

Condition Name

Condition Name for Xpovio
Intervention Trials
Multiple Myeloma 2
Coronavirus Infection 2
Recurrent Plasma Cell Myeloma 2
Malignant Glioma 2
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Condition MeSH

Condition MeSH for Xpovio
Intervention Trials
Neoplasms, Plasma Cell 6
Multiple Myeloma 6
Carcinoma 4
Neoplasms 3
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Clinical Trial Locations for Xpovio

Trials by Country

Trials by Country for Xpovio
Location Trials
United States 75
Greece 4
Denmark 3
Israel 2
Canada 2
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Trials by US State

Trials by US State for Xpovio
Location Trials
New York 7
Florida 5
Texas 5
California 5
Michigan 4
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Clinical Trial Progress for Xpovio

Clinical Trial Phase

Clinical Trial Phase for Xpovio
Clinical Trial Phase Trials
Phase 2 10
Phase 1/Phase 2 5
Phase 1 5
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Clinical Trial Status

Clinical Trial Status for Xpovio
Clinical Trial Phase Trials
Recruiting 12
Not yet recruiting 4
Completed 3
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Clinical Trial Sponsors for Xpovio

Sponsor Name

Sponsor Name for Xpovio
Sponsor Trials
Karyopharm Therapeutics Inc 12
National Cancer Institute (NCI) 10
Karyopharm Therapeutics, Inc 3
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Sponsor Type

Sponsor Type for Xpovio
Sponsor Trials
Industry 16
Other 11
NIH 10
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Serving leading biopharmaceutical companies globally:

Medtronic
Baxter
Dow
AstraZeneca
Johnson and Johnson
Express Scripts

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