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Generated: December 17, 2018

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CLINICAL TRIALS PROFILE FOR XALKORI

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Clinical Trials for Xalkori

Trial ID Title Status Sponsor Phase Summary
NCT01531361 Sorafenib or Crizotinib and Vemurafenib in Advanced Cancer Recruiting M.D. Anderson Cancer Center Phase 1 The goal of this clinical research study is to find the highest tolerable dose of the combination of ZelborafTM (vemurafenib) with Nexavar® (sorafenib) or Xalkori® (crizotinib) that can be given to patients with advanced cancer. The safety of these drugs will also be studied. Vemurafenib is designed to block a protein called BRAF V600E inside the cancer cells, which is involved in cancer cell growth. Sorafenib is designed to block the function of important proteins in and outside of cancer cells. These proteins are involved in cancer cells growth and new blood vessel development. Crizotinib is designed to block certain abnormal genes found in cancer cells. This may cause the cancer cells to die.
NCT01548144 Pazopanib or Pemetrexed and Crizotinib in Advanced Cancer Active, not recruiting M.D. Anderson Cancer Center Phase 1 The goal of this clinical research study is to find the highest tolerable dose of the combination of Xalkori (crizotinib) either with Votrient (pazopanib) or Alimta (pemetrexed) or of the combination of 3 study drugs that can be given to patients with advanced cancer. The safety of these drug combinations will also be studied. Crizotinib is designed to block a protein called ALK, which is involved in cancer cell growth and survival. Pazopanib is designed to block the growth of blood vessels that supply nutrients needed for tumor growth. This may prevent or slow the growth of cancer cells. Pemetrexed is designed to block proteins that may cause tumors to grow.
NCT01597258 Safety And Efficacy Of Crizotinib (Regulatory Post Marketing Commitment Plan) Active, not recruiting Pfizer N/A The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the LPD (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3)factors considered to affect the safety and/or efficacy of this drug.
NCT01712217 A Study of AT13387 in Patients With Non-Small Cell Lung Cancer (NSCLC) Alone and in Combination With Crizotinib Active, not recruiting Astex Pharmaceuticals Phase 1/Phase 2 The purpose of the study is to evaluate safety and efficacy of AT13387 Alone and in Combination with Crizotinib in the Treatment of Non-small Cell Lung Cancer.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Xalkori

Condition Name

Condition Name for Xalkori
Intervention Trials
Carcinoma, Non-Small-Cell Lung 4
Advanced Cancers 3
Stage IIIA Non-Small Cell Lung Cancer 2
Non-small Cell Lung Cancer 2
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Condition MeSH

Condition MeSH for Xalkori
Intervention Trials
Carcinoma, Non-Small-Cell Lung 13
Lung Neoplasms 8
Neoplasms 5
Lymphoma, Non-Hodgkin 2
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Clinical Trial Locations for Xalkori

Trials by Country

Trials by Country for Xalkori
Location Trials
United States 290
Japan 21
China 12
Italy 8
Germany 7
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Trials by US State

Trials by US State for Xalkori
Location Trials
Texas 11
Michigan 10
Pennsylvania 10
North Carolina 9
Missouri 9
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Clinical Trial Progress for Xalkori

Clinical Trial Phase

Clinical Trial Phase for Xalkori
Clinical Trial Phase Trials
Phase 3 5
Phase 2 15
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Xalkori
Clinical Trial Phase Trials
Recruiting 16
Active, not recruiting 7
Not yet recruiting 5
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Clinical Trial Sponsors for Xalkori

Sponsor Name

Sponsor Name for Xalkori
Sponsor Trials
Pfizer 15
National Cancer Institute (NCI) 6
M.D. Anderson Cancer Center 3
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Sponsor Type

Sponsor Type for Xalkori
Sponsor Trials
Industry 26
Other 24
NIH 6
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