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Generated: December 11, 2018

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CLINICAL TRIALS PROFILE FOR WELLBUTRIN SR

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Clinical Trials for WELLBUTRIN SR

Trial ID Title Status Sponsor Phase Summary
NCT00000457 Pharmacologic Relapse Prevention for Alcoholic Smokers Completed National Institute on Alcohol Abuse and Alcoholism (NIAAA) Phase 2 This study will compare the long-term use of bupropion (Wellbutrin) and placebo for reducing the rate of smoking relapse in recovering alcoholics who achieved initial abstinence from smoking with nicotine patch therapy. The study will also determine the cessation rate in the 8th week of treatment among recovering alcoholics using a nicotine patch. The patch dose is projected to serve as a 100-percent replacement.
NCT00000457 Pharmacologic Relapse Prevention for Alcoholic Smokers Completed Mayo Clinic Phase 2 This study will compare the long-term use of bupropion (Wellbutrin) and placebo for reducing the rate of smoking relapse in recovering alcoholics who achieved initial abstinence from smoking with nicotine patch therapy. The study will also determine the cessation rate in the 8th week of treatment among recovering alcoholics using a nicotine patch. The patch dose is projected to serve as a 100-percent replacement.
NCT00001483 Acute Effectiveness of Additional Drugs to the Standard Treatment of Depression Completed National Institute of Mental Health (NIMH) Phase 2 This study will compare the effectiveness of relatively new antidepressants which have different mechanisms of action. Buproprion (Wellbutrin) works on dopamine and the dopaminergic pathway. Sertraline (Zoloft) works as a selective serotonin reuptake inhibitor (SSRI). Venlafaxine (Effexor) works as a mixed serotonin, norepinephrine, and dopamine reuptake inhibitor. Subjects enrolled in this study will be patients diagnosed with a bipolar disorder who are presently taking medication to prevent the symptoms of the disease (prophylactic treatment), but have had breakthrough episodes of depression despite taking their medication. Patients will receive any one of the three antidepressant medications as noted above plus a placebo inactive sugar pill, in order to mask which antidepressant is being prescribed) in addition to their regular medication for bipolar disorder. All of the doses will be calculated as effective for the treatment of a unipolar major depressive disorder. The patient will continue receiving the medication for ten weeks. The effectiveness of the drug treatment will be measured by using three different scales; 1. Inventory for Depressive Symptoms - Clinicians form (IDS-C) 2. Clinical Global Impression scale(CGI-BP) 3. Life Charting Methodology (LCM) Patients who do not respond to their medication within ten weeks from the beginning of the study will be considered as non-responders and be offered the opportunity to start the study again, taking one of the two remaining medications. For example, if a patient was assigned to take Wellbutrin but it was ineffective, he/she could re-enter the study and be given either Zoloft or Effexor. Patients that do respond in the first ten weeks of the study will be eligible to continue taking the medication for one year to assess the long term effectiveness of the drug on preventing episodes of depression and to assess for any possible differential induction of mania.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for WELLBUTRIN SR

Condition Name

Condition Name for WELLBUTRIN SR
Intervention Trials
Major Depressive Disorder 10
Depression 6
Healthy 6
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Condition MeSH

Condition MeSH for WELLBUTRIN SR
Intervention Trials
Depression 23
Depressive Disorder 21
Depressive Disorder, Major 17
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Clinical Trial Locations for WELLBUTRIN SR

Trials by Country

Trials by Country for WELLBUTRIN SR
Location Trials
United States 85
Canada 7
Korea, Republic of 4
Mexico 1
Malaysia 1
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Trials by US State

Trials by US State for WELLBUTRIN SR
Location Trials
New York 11
California 7
Florida 7
Texas 6
Pennsylvania 5
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Clinical Trial Progress for WELLBUTRIN SR

Clinical Trial Phase

Clinical Trial Phase for WELLBUTRIN SR
Clinical Trial Phase Trials
Phase 4 25
Phase 3 1
Phase 2/Phase 3 8
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Clinical Trial Status

Clinical Trial Status for WELLBUTRIN SR
Clinical Trial Phase Trials
Completed 38
Recruiting 12
Unknown status 5
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Clinical Trial Sponsors for WELLBUTRIN SR

Sponsor Name

Sponsor Name for WELLBUTRIN SR
Sponsor Trials
National Institute on Drug Abuse (NIDA) 11
GlaxoSmithKline 9
New York State Psychiatric Institute 6
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Sponsor Type

Sponsor Type for WELLBUTRIN SR
Sponsor Trials
Other 68
NIH 25
Industry 19
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Serving hundreds of leading biopharmaceutical companies globally:

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