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Federal Trade Commission
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Cipla
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Generated: February 17, 2019

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CLINICAL TRIALS PROFILE FOR VOTRIENT

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Clinical Trials for Votrient

Trial ID Title Status Sponsor Phase Summary
NCT00334282 Safety and Efficacy of GW786034 (Pazopanib) In Metastatic Renal Cell Carcinoma Completed GlaxoSmithKline Phase 3 To evaluate efficacy and safety of pazopanib compared to placebo in patients with locally advanced and/ or metastatic renal cell carcinoma (RCC). Approximately 350-400 eligible patients will be stratified and randomized in a 2:1 ratio to receive either 800 mg pazopanib once daily or matching placebo. The study treatment will continue until patients experience disease progression, unacceptable toxicity or death. Primary objective of the study is to evaluate and compare the two treatment arms for progression-free survival. Principal secondary objective is to evaluate and compare the two treatment arms with respect to overall survival. Other objectives are overall response rate [complete response (CR) + partial response (PR)], rate of CR + PR + 6 months stable disease, and the incidence, severity and causality of adverse events and serious adverse events. Safety and efficacy assessments will be regularly performed on all patients. An Independent Data Monitoring Committee will be established to monitor safety during the course of the study and to evaluate interim efficacy data on overall survival.
NCT00388076 Pazopanib (VOTRIENT) Plus Paclitaxel (TAXOL), Pazopanib Plus Paclitaxel (TAXOL) Plus Carboplatin (PARAPLATIN), and Pazopanib Plus Paclitaxel (TAXOL) Plus Lapatinib (TYKERB) Completed GlaxoSmithKline Phase 1 Pazopanib will be given with TAXOL in one part, in another part pazopanib will be given with TAXOL and PARAPLATIN, and in a third part pazopanib will be given with TAXOL and lapatinib (patients separated in each part). Toxicity monitoring will enable us to find the largest dose of pazopanib daily that can be safely given in combination with the chemotherapy agents TAXOL and PARAPLATIN, and with lapatinib, as well as what side effects are likely to manifest when these agents are given together and whether the combination of pazopanib with chemotherapy, helps to treat different types of cancer. Another objective is to find out how much pazopanib, TAXOL, PARAPLATIN and lapatinib are in the blood at specific times after the agents are given. Collecting the blood samples requires that the patients remain in the vicinity of the clinic overnight on 2 occasions.
NCT00450879 Pazopanib in Treating Patients With Newly Diagnosed or Locally and/or Regionally Recurrent Breast Cancer That Can Be Removed By Surgery Terminated National Cancer Institute (NCI) Phase 1 This pilot clinical trial studies how well pazopanib hydrochloride works in treating patients with breast cancer that is newly diagnosed or has come back at or near the same place as the original tumor and can be removed by surgery. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by preventing the growth of new blood vessels necessary for tumor growth. Giving pazopanib hydrochloride before surgery may make the tumor smaller and reduce the amount of tissue that needs to be removed.
NCT00454142 Pazopanib Hydrochloride in Treating Patients With Stage IV or Recurrent Nasopharyngeal Cancer Completed National Cancer Institute (NCI) Phase 2 This phase II trial studies the side effects and how well pazopanib hydrochloride works in treating patients with stage IV or recurrent nasopharyngeal cancer. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Votrient

Condition Name

Condition Name for Votrient
Intervention Trials
Stage IV Renal Cell Cancer 7
Clear Cell Renal Cell Carcinoma 7
Carcinoma, Renal Cell 7
Renal Cell Carcinoma 5
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Condition MeSH

Condition MeSH for Votrient
Intervention Trials
Carcinoma 27
Carcinoma, Renal Cell 26
Sarcoma 19
Neoplasms 9
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Clinical Trial Locations for Votrient

Trials by Country

Trials by Country for Votrient
Location Trials
United States 483
Germany 55
Italy 38
Canada 34
United Kingdom 15
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Trials by US State

Trials by US State for Votrient
Location Trials
Texas 26
California 20
Minnesota 19
Michigan 19
Florida 18
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Clinical Trial Progress for Votrient

Clinical Trial Phase

Clinical Trial Phase for Votrient
Clinical Trial Phase Trials
Phase 4 2
Phase 3 6
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Votrient
Clinical Trial Phase Trials
Completed 28
Recruiting 25
Active, not recruiting 25
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Clinical Trial Sponsors for Votrient

Sponsor Name

Sponsor Name for Votrient
Sponsor Trials
National Cancer Institute (NCI) 33
GlaxoSmithKline 33
Novartis 9
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Sponsor Type

Sponsor Type for Votrient
Sponsor Trials
Other 89
Industry 59
NIH 33
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Serving hundreds of leading biopharmaceutical companies globally:

Fuji
US Department of Justice
Johnson and Johnson
QuintilesIMS
Julphar
Cipla
Cerilliant
US Army
Moodys

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