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Last Updated: December 12, 2024

CLINICAL TRIALS PROFILE FOR VISMODEGIB


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All Clinical Trials for Vismodegib

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00636610 ↗ A Study of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) With Concurrent Chemotherapy and Bevacizumab As First-Line Therapy for Metastatic Colorectal Cancer Completed Genentech, Inc. Phase 2 2008-05-01 This was a randomized, placebo-controlled, double-blind study of vismodegib (GDC-0449) added to biochemotherapy standard-of-care regimens for metastatic colorectal cancer (CRC), with treatment until disease progression. Patients received either FOLFOX (FOL=leucovorin calcium [folinic acid], F=fluorouracil, OX=oxaliplatin) or FOLFIRI (FOL=leucovorin calcium [folinic acid] F=fluorouracil, IRI=irinotecan hydrochloride) chemotherapy with bevacizumab. The decision of which regimen (FOLFOX or FOLFIRI) to use was made by the treating physician and patient. Patients were randomized to receive vismodegib or placebo and were stratified based on the chemotherapy regimen chosen and whether or not Response Evaluation Criteria in Solid Tumors (RECIST) measurable disease was present at baseline.
NCT00739661 ↗ A Study of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) As Maintenance Therapy in Patients With Ovarian Cancer in a Second or Third Complete Remission Completed Genentech, Inc. Phase 2 2008-12-01 The study was a Phase II, randomized, placebo-controlled, double-blind, multicenter clinical trial of vismodegib (GDC-0449) in patients with ovarian cancer in a second or third complete remission. Patients were randomized in a 1:1 ratio to either vismodegib or placebo. Randomization was stratified based on whether their cancer was in a second or third complete remission.
NCT00822458 ↗ GDC-0449 in Treating Young Patients With Medulloblastoma That is Recurrent or Did Not Respond to Previous Treatment Completed National Cancer Institute (NCI) Phase 1 2009-01-01 This phase I trial is studying the side effects and best dose of GDC-0449 in treating young patients with medulloblastoma that is recurrent or did not respond to previous treatment. GDC-0449 may be effective in treating young patients with medulloblastoma.
NCT00833417 ↗ A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) in Patients With Advanced Basal Cell Carcinoma Completed Genentech, Inc. Phase 2 2009-02-01 This was a Phase II, single-arm, two-cohort multicenter clinical trial evaluating the efficacy and safety of vismodegib (GDC-0449) in patients with advanced basal cell carcinoma. All patients received vismodegib until evidence of progression, intolerable toxicities most probably attributable to vismodegib, or withdrawal from the study.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Vismodegib

Condition Name

Condition Name for Vismodegib
Intervention Trials
Basal Cell Carcinoma 15
Stage IV Pancreatic Cancer 4
Carcinoma, Basal Cell 4
Refractory Plasma Cell Myeloma 3
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Condition MeSH

Condition MeSH for Vismodegib
Intervention Trials
Carcinoma 31
Carcinoma, Basal Cell 25
Neoplasms 9
Adenocarcinoma 9
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Clinical Trial Locations for Vismodegib

Trials by Country

Trials by Country for Vismodegib
Location Trials
United States 374
Italy 30
Canada 24
France 17
Spain 16
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Trials by US State

Trials by US State for Vismodegib
Location Trials
California 26
Texas 19
New York 18
Pennsylvania 18
Michigan 18
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Clinical Trial Progress for Vismodegib

Clinical Trial Phase

Clinical Trial Phase for Vismodegib
Clinical Trial Phase Trials
Phase 4 2
Phase 2 49
Phase 1/Phase 2 7
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Clinical Trial Status

Clinical Trial Status for Vismodegib
Clinical Trial Phase Trials
Completed 38
Recruiting 12
Terminated 11
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Clinical Trial Sponsors for Vismodegib

Sponsor Name

Sponsor Name for Vismodegib
Sponsor Trials
Genentech, Inc. 23
National Cancer Institute (NCI) 21
Hoffmann-La Roche 12
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Sponsor Type

Sponsor Type for Vismodegib
Sponsor Trials
Other 75
Industry 70
NIH 21
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