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Generated: December 15, 2018

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CLINICAL TRIALS PROFILE FOR VALPROIC ACID

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Clinical Trials for Valproic Acid

Trial ID Title Status Sponsor Phase Summary
NCT00000629 The Effects of Valproic Acid on Zidovudine Glucuronidation and Pharmacokinetics in HIV-Infected Patients. Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 Primary objective: To study the pharmacokinetic interaction between zidovudine (AZT) and valproic acid in asymptomatic HIV-infected patients, characterizing AZT's oral bioavailability, plasma elimination half-time, plasma levels, and urinary excretion of AZT, 5'-O-glucuronide (GAZT), and 3'-amino-3'-deoxythymidine (AMT). Secondary objective: To establish the safety of short-term administration of AZT and valproic acid in combination with regard to hematologic parameters and liver function in asymptomatic HIV-infected patients. Preliminary studies using human liver tissue have shown that valproic acid inhibits the metabolic inactivation of zidovudine (AZT), which may prolong the plasma half-life of AZT and thus prolong the duration of the drug's effects in the body.
NCT00004758 Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment Completed National Institute of Neurological Disorders and Stroke (NINDS) Phase 2 OBJECTIVES: I. Evaluate the efficacy of surgical resection of an identifiable zone of cortical abnormality versus multiple drug therapy in children with infantile spasms refractory to standard therapy. II. Assess how infantile spasms interfere with development and whether this is partially reversible. III. Determine the predictors of good surgical outcome and whether surgery permanently controls seizures and improves development.
NCT00004758 Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment Completed University of California, Los Angeles Phase 2 OBJECTIVES: I. Evaluate the efficacy of surgical resection of an identifiable zone of cortical abnormality versus multiple drug therapy in children with infantile spasms refractory to standard therapy. II. Assess how infantile spasms interfere with development and whether this is partially reversible. III. Determine the predictors of good surgical outcome and whether surgery permanently controls seizures and improves development.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Valproic Acid

Condition Name

Condition Name for Valproic Acid
Intervention Trials
Epilepsy 13
Bipolar Disorder 10
Seizures 7
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Condition MeSH

Condition MeSH for Valproic Acid
Intervention Trials
Leukemia 20
Leukemia, Myeloid 14
Leukemia, Myeloid, Acute 13
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Clinical Trial Locations for Valproic Acid

Trials by Country

Trials by Country for Valproic Acid
Location Trials
United States 232
Germany 21
Italy 16
Canada 12
Brazil 8
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Trials by US State

Trials by US State for Valproic Acid
Location Trials
Texas 22
Maryland 17
California 13
Ohio 13
Pennsylvania 11
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Clinical Trial Progress for Valproic Acid

Clinical Trial Phase

Clinical Trial Phase for Valproic Acid
Clinical Trial Phase Trials
Phase 4 26
Phase 3 14
Phase 2/Phase 3 4
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Clinical Trial Status

Clinical Trial Status for Valproic Acid
Clinical Trial Phase Trials
Completed 88
Recruiting 25
Terminated 19
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Clinical Trial Sponsors for Valproic Acid

Sponsor Name

Sponsor Name for Valproic Acid
Sponsor Trials
National Cancer Institute (NCI) 17
Abbott 12
M.D. Anderson Cancer Center 12
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Sponsor Type

Sponsor Type for Valproic Acid
Sponsor Trials
Other 177
Industry 53
NIH 28
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Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
Deloitte
Farmers Insurance
Johnson and Johnson
Teva
QuintilesIMS
Fish and Richardson
Harvard Business School
Accenture

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