Comparison of the Pharmacokinetics of Three Generic Medications and Their Respective Brand Preparations
University of Ottawa
Generic describes a pharmaceutical product that does not have a brand name or trademark.
Generic medications should be the equivalent of brand medications. Only their price should
be different. The active ingredient of the generic medication has to be within a window of
80 to 125% of the original in the blood. There are reports that this standard is not always
followed after the medication has been on the market. Indeed, it was observed that some
patients previously stable on original medications relapsed when switched to a generic.
Several factors could account for this problem. Such problems have been reported for
Pindolol, Quetiapine, and Trazodone. Some properties of specific brands of the generics and
the original brands will be examined for these three medications. The three original
medications used in this study are the Visken, the Seroquel, and the Desyrel. The three
generics are the Teva-pindolol, the Teva-Quetiapine, and the Teva-Trazodone. They are all
available on the Canadian market by prescription.
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