A Relative Bioavailability Study of Moexipril HCl 15 mg Tablets Under Fasting Conditions
Completed
Paddock Laboratories, Inc.
Phase 1
1969-12-31
The purpose of this study is to compare the relative bioavailability of Moexipril HCl 15mg
tablets (by Paddock Laboratories, Inc.) with that of Univasc® 15mg tablets (by Schwarz
Pharma) following a single oral dose (1 x 15mg tablet) in healthy, adult subjects under
fasting conditions.
Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery
Completed
University of Nebraska
Phase 4
2015-06-01
Primary research hypothesis: Patients who continue their chronic ACEI therapy up to and
including the morning of a non-cardiac, non-vascular surgery will experience more
intraoperative hypotension than those who transiently hold their chronic ACEI preoperatively.
Secondary research hypothesis #1: Patients who continue their chronic ACEI up to and
including the morning of a non-cardiac, non-vascular surgery will experience better
postoperative control of hypertension than those who transiently hold their chronic ACEI
preoperatively.
Secondary research hypothesis #2: Patients who continue their chronic ACEI up to and
including the morning of a non-cardiac, non-vascular surgery will experience less acute renal
failure than those who transiently hold their chronic ACEI preoperatively.
Secondary research hypothesis #3: In the subgroup of patients with a preoperative systolic
blood pressure less than 110 mmHg, those who continue their chronic ACEI therapy up to and
including the morning of a non-cardiac, non-vascular surgery will experience more
intraoperative hypotension than those who transiently hold their chronic ACEI preoperatively.
Secondary research hypothesis #4: In the subgroup of patients above the age of 64, those who
continue their chronic ACEI therapy up to and including the morning of a non-cardiac,
non-vascular surgery will experience more intraoperative hypotension than those who
transiently hold their chronic ACEI preoperatively.
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