CLINICAL TRIALS PROFILE FOR TRENTAL

All Clinical Trials for Trental

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00000646 ↗	Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS	Completed	Hoechst Marion Roussel	Phase 1	1969-12-31	To determine whether pentoxifylline lowers tumor necrosis factor (TNF) levels in AIDS patients. Pentoxifylline decreases tumor necrosis factor (TNF), and therefore should decrease such TNF-intensified events as cachexia, enhanced HIV expression, and inhibition of zidovudine (AZT) activity.
NCT00000646 ↗	Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS	Completed	National Institute of Allergy and Infectious Diseases (NIAID)	Phase 1	1969-12-31	To determine whether pentoxifylline lowers tumor necrosis factor (TNF) levels in AIDS patients. Pentoxifylline decreases tumor necrosis factor (TNF), and therefore should decrease such TNF-intensified events as cachexia, enhanced HIV expression, and inhibition of zidovudine (AZT) activity.
NCT00243789 ↗	Study of Daily Pentoxifylline as a Rescue Treatment in Duchenne Muscular Dystrophy	Completed	Cooperative International Neuromuscular Research Group	Phase 1/Phase 2	2005-09-01	The purpose of this study is to see if male children with Duchenne muscular dystrophy (DMD) have changes in strength when given the drug Pentoxifylline as a rescue treatment. A total of 64 subjects are expected to participate through all other centers of the Cooperative International Neuromuscular Research Group (CINRG) worldwide. The primary purpose of this study is to see whether the addition of pentoxifylline to a steroid regimen is effective in treating deteriorating muscle strength by comparing the muscle strength of PTX treated subjects and placebo treated subjects.
NCT00267670 ↗	Pentoxifylline/Nonalcoholic Steatohepatitis (NASH) Study: The Effect of Pentoxifylline on NASH	Completed	Northwestern University	Phase 2/Phase 3	2005-03-01	The purpose of this study is to explore the potential benefit of the medication, pentoxifylline, for the treatment of NASH.
NCT00354198 ↗	Efficacy of Pentoxifylline on Rapidly Progressive Glomerulonephritis	Terminated	National Science Council, Taiwan	Phase 3	2006-08-01	We have recently demonstrated that pentoxifylline (PTX) has the potential to treat severe glomerular inflammation in a rat model of accelerated anti-glomerular basement membrane (GBM) glomerulonephritis. This study aims to investigate the therapeutic effects of combined PTX and conventional immunosuppressive regimens on patients with rapidly progressive glomerulonephritis.
NCT00354198 ↗	Efficacy of Pentoxifylline on Rapidly Progressive Glomerulonephritis	Terminated	National Taiwan University Hospital	Phase 3	2006-08-01	We have recently demonstrated that pentoxifylline (PTX) has the potential to treat severe glomerular inflammation in a rat model of accelerated anti-glomerular basement membrane (GBM) glomerulonephritis. This study aims to investigate the therapeutic effects of combined PTX and conventional immunosuppressive regimens on patients with rapidly progressive glomerulonephritis.
NCT00354731 ↗	Efficacy of Pentoxifylline on Primary Nephrotic Syndrome	Completed	National Science Council, Taiwan	Phase 3	2006-08-01	We aim to investigate (1) the effects of combined pentoxifylline and corticosteroids, compared to that of corticosteroids, on patients with primary nephrotic syndrome; and if possible (2) the effects of pentoxifylline monotherapy on patients with primary nephrotic syndrome not suitable for or intolerant of standard corticosteroid therapy.

Clinical Trial Conditions for Trental

Condition Name

Condition Name for Trental
Intervention	Trials
Inflammation	2
Acute Pancreatitis (AP)	1
Fibrosis	1
Nonalcoholic Steatohepatitis (NASH)	1

Condition MeSH

Condition MeSH for Trental
Intervention	Trials
Kidney Diseases	5
Renal Insufficiency, Chronic	4
Depression	3
Infertility	3

Clinical Trial Locations for Trental

Trials by Country

Trials by Country for Trental
Location	Trials
United States	29
Egypt	7
Taiwan	3
Mexico	2
Canada	2

Trials by US State

Trials by US State for Trental
Location	Trials
Texas	3
Ohio	3
Minnesota	3
Michigan	2
Oregon	2

Clinical Trial Progress for Trental

Clinical Trial Phase

Clinical Trial Phase for Trental
Clinical Trial Phase	Trials
Phase 4	7
Phase 3	8
Phase 2/Phase 3	2

Clinical Trial Status

Clinical Trial Status for Trental
Clinical Trial Phase	Trials
Completed	20
Recruiting	8
Unknown status	7

Clinical Trial Sponsors for Trental

Sponsor Name

Sponsor Name for Trental
Sponsor	Trials
Ain Shams University	3
National Taiwan University Hospital	3
Tanta University	2

Sponsor Type

Sponsor Type for Trental
Sponsor	Trials
Other	72
Industry	8
NIH	4