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Generated: February 21, 2019

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CLINICAL TRIALS PROFILE FOR TRAMADOL HYDROCHLORIDE

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Clinical Trials for Tramadol Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00058357 Lidocaine Patch in Treating Cancer Patients With Neuropathic Pain After Surgery Completed National Cancer Institute (NCI) Phase 3 RATIONALE: A lidocaine patch may be effective in relieving numbness, tingling, and other symptoms of neuropathy. It is not yet known whether a lidocaine patch is effective in treating neuropathy in patients who have undergone surgery for cancer. PURPOSE: This randomized phase III trial is studying lidocaine patch to see how well it works compared to a placebo patch in relieving numbness, tingling, and other symptoms of neuropathy in patients who have undergone surgery for cancer.
NCT00058357 Lidocaine Patch in Treating Cancer Patients With Neuropathic Pain After Surgery Completed Alliance for Clinical Trials in Oncology Phase 3 RATIONALE: A lidocaine patch may be effective in relieving numbness, tingling, and other symptoms of neuropathy. It is not yet known whether a lidocaine patch is effective in treating neuropathy in patients who have undergone surgery for cancer. PURPOSE: This randomized phase III trial is studying lidocaine patch to see how well it works compared to a placebo patch in relieving numbness, tingling, and other symptoms of neuropathy in patients who have undergone surgery for cancer.
NCT00111046 Pain Relief - Tramadol Versus Ibuprofen Unknown status Royal Liverpool University Hospital Phase 1/Phase 2 The purpose of this study is to assess post operative pain following the insertion of radioactive plaque for choroidal melanoma in patients after receiving either ibuprofen or tramadol.
NCT00115752 Genetic Basis For Variation In NSAID Analgesia In A Clinical Model Of Acute Pain Completed National Institute of Nursing Research (NINR) Phase 2 This study will evaluate how genetic makeup contributes to the variation in people regarding their sensitivity to and experience of pain. Scientists believe that differences in information found in genes may explain why an analgesic drug, that is, one that treats pain, works effectively for some people but not for others. The study will explore pain that is acute (fast and short period). Knowledge gained from this ongoing study may permit development of an individualized analgesic drug prescription. Patients ages 16 to 35 who are in good health and have been referred for removal of impacted wisdom teeth; who are not allergic to aspirin or other nonsteroidal anti-inflammatory drugs (known as NSAIDs), sulfites, or certain anesthetics; who are not pregnant or nursing; and who are willing to have a biopsy before and after dental surgery are eligible for this study. Patients will come to the clinic for one test visit and one treatment visit. During the first visit, a questionnaire will evaluate patients' psychological state, including mood and depression. There will be a clinical examination of their wisdom teeth. A blood sample of 10 milliliters (about 0.4 ounces) will be collected from the forearm to provide DNA material containing genes stored in cells. The primary genetic analysis will be done at NIH, although the DNA collected might also be sent to a laboratory outside NIH. DNA samples will be coded so that names of patients cannot be traced. During the second visit, two of the patients' lower wisdom teeth will be removed. Patients will be given a local anesthetic in the mouth and a sedative given through a vein in the arm. While the mouth is numb, a small piece of tissue will be removed from inside the cheek, near the wisdom tooth. It is the first biopsy. After the two wisdom teeth are removed, a small piece of tubing will be placed into both sides of the mouth where the teeth were removed. Every 20 minutes, for the next 3 hours, the researchers will collect inflammatory fluid from the tubing, to measure the chemicals thought to cause pain and swelling. Also every 20 minutes, patients will rate the pain they feel by answering questions. If there is pain before 3 hours following surgery, they will receive a dose of fentanyl to relieve moderate to severe pain. A second biopsy will occur 3 hours after surgery, to measure changes in chemicals produced in response to surgery. Immediately afterward, patients will receive 30 mg of ketorolac (Toradol) whether or not pain is felt. They will answer questionnaires about pain for 3 hours after receiving the drug, to rate how well it works. They will stay at the clinic up to 6 hours after the surgery. If pain is not relieved with ketorolac, patients will receive a one-time dose of tramadol, a pain medication for moderate to severe pain. After the study procedures are completed, patients will receive pain medication for pain after surgery. Patients will be monitored closely, because all drugs have side effects. Ketorolac is a nonsteroidal anti-inflammatory drug, one that may cause gastrointestinal upset. Fentanyl is a powerful narcotic drug that is safe at the dosage used in this study, but stomach upset, dizziness, and breathing trouble may occur. Also, risks from the biopsy include discomfort from injecting the numbing medicine, infection, and bleeding. There may be discomfort from the sedative injected into the vein, and there may be bruising. Benefits from participating are having wisdom teeth removed at no cost as well as close monitoring before and after surgery. There are no plans to give patients the results of genetic tests or questionnaires. Years of research may be needed before such information has the chance to become meaningful.
NCT00142896 Tramadol to Reduce Opioid Withdrawal Symptoms Completed National Institute on Drug Abuse (NIDA) Phase 2 Individuals with opioid addiction often experience serious withdrawal symptoms that may make relapse unavoidable. Tramadol, a medication that is currently used to treat pain caused by chronic conditions such as cancer or joint pain, may also be effective at reducing opioid withdrawal symptoms. This study will evaluate the effectiveness of tramadol at reducing withdrawal symptoms in individuals addicted to opioid drugs.
NCT00163553 Neuraxial Pethidine After Lumbar Surgery Trial Unknown status Austin Health Phase 3 The hypothesis is that epidural pethidine is an effective form of pain relief following lumbar spinal surgery, resulting in significantly lower usage of concomitantly administered (intravenous) patient-controlled analgesia (PCA) pethidine.
NCT00210561 A Study of the Effectiveness and Safety of Tramadol HCl/Acetaminophen Compared to Placebo in Treating Acute Low Back Pain Terminated PriCara, Unit of Ortho-McNeil, Inc. Phase 4 The purpose of this study is to explore the pain-relieving effects and safety of Tramadol HCl/acetaminophen as compared to placebo in patients experiencing acute low back pain. Tramadol HCl/acetaminophen is approved for short-term management of acute pain. The combination of tramadol HCl/acetaminophen has been shown to be effective for the treatment of acute musculoskeletal pain. Patients who experienced at least moderate acute low back pain for 2 to 10 days before study entry will be randomized to receive either tramadol HCl/acetaminophen or placebo.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Tramadol Hydrochloride

Condition Name

Condition Name for Tramadol Hydrochloride
Intervention Trials
Pain 53
Postoperative Pain 27
Pain, Postoperative 20
Healthy 15
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Condition MeSH

Condition MeSH for Tramadol Hydrochloride
Intervention Trials
Pain, Postoperative 61
Osteoarthritis 26
Chronic Pain 14
Back Pain 13
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Clinical Trial Locations for Tramadol Hydrochloride

Trials by Country

Trials by Country for Tramadol Hydrochloride
Location Trials
United States 124
Turkey 24
Egypt 17
Brazil 14
Italy 13
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Trials by US State

Trials by US State for Tramadol Hydrochloride
Location Trials
Maryland 10
Texas 8
California 7
Kansas 7
Minnesota 6
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Clinical Trial Progress for Tramadol Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Tramadol Hydrochloride
Clinical Trial Phase Trials
Phase 4 134
Phase 3 61
Phase 2/Phase 3 4
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Clinical Trial Status

Clinical Trial Status for Tramadol Hydrochloride
Clinical Trial Phase Trials
Completed 177
Recruiting 55
Not yet recruiting 35
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Clinical Trial Sponsors for Tramadol Hydrochloride

Sponsor Name

Sponsor Name for Tramadol Hydrochloride
Sponsor Trials
Labopharm Inc. 15
Cairo University 12
Janssen Korea, Ltd., Korea 10
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Sponsor Type

Sponsor Type for Tramadol Hydrochloride
Sponsor Trials
Other 266
Industry 109
U.S. Fed 10
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