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CLINICAL TRIALS PROFILE FOR TOPOTECAN HYDROCHLORIDE

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Clinical Trials for Topotecan Hydrochloride

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00001333	Phase I Study of Intrathecal Topotecan	Completed	National Cancer Institute (NCI)	Phase 1	The purpose of this study is to determine the qualitative and quantitative toxicity of intrathecal topotecan, a topoisomerase I inhibitor, in patients with meningeal malignancies refractory to conventional therapy (radiation therapy and chemotherapy).
NCT00002395	Safety and Effectiveness of Topotecan HCl to Treat HIV-Infected Patients With AIDS-Related Progressive Multifocal Leukoencephalopathy (PML)	Completed	SmithKline Beecham	Phase 2	The purpose of this study is to see if it is safe and effective to give topotecan through a vein to treat HIV-infected patients with PML, an opportunistic (AIDS-related) infection caused by a virus that infects brain tissue and causes damage to the brain and the spinal cord. Topotecan fights HIV and the JC virus (the virus that causes PML) in laboratory experiments.
NCT00002515	Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer	Completed	Memorial Sloan Kettering Cancer Center	Phase 2	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Bone marrow transplantation may allow doctors to give higher doses of chemotherapy and kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy with thiotepa, carboplatin, and topotecan followed by bone marrow transplantation in treating patients who have metastatic or progressive rare cancer.

Clinical Trial Conditions for Topotecan Hydrochloride

Condition Name

Condition Name for Topotecan Hydrochloride
Intervention	Trials
Ovarian Cancer	70
Small Cell Lung Cancer	32
Neuroblastoma	29

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Condition MeSH

Condition MeSH for Topotecan Hydrochloride
Intervention	Trials
Lung Neoplasms	78
Small Cell Lung Carcinoma	76
Ovarian Neoplasms	74

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Clinical Trial Locations for Topotecan Hydrochloride

Trials by Country

Trials by Country for Topotecan Hydrochloride
Location	Trials
Canada	129
Germany	48
Australia	39
Italy	35
United Kingdom	33

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Trials by US State

Trials by US State for Topotecan Hydrochloride
Location	Trials
California	74
New York	72
Ohio	71
Texas	68
Florida	67

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Clinical Trial Progress for Topotecan Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Topotecan Hydrochloride
Clinical Trial Phase	Trials
Phase 4	1
Phase 3	46
Phase 2/Phase 3	3

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Clinical Trial Status

Clinical Trial Status for Topotecan Hydrochloride
Clinical Trial Phase	Trials
Completed	206
Recruiting	49
Terminated	36

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Clinical Trial Sponsors for Topotecan Hydrochloride

Sponsor Name

Sponsor Name for Topotecan Hydrochloride
Sponsor	Trials
National Cancer Institute (NCI)	128
GlaxoSmithKline	57
Children's Oncology Group	14

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Sponsor Type

Sponsor Type for Topotecan Hydrochloride
Sponsor	Trials
Other	340
Industry	161
NIH	133

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