The Effects of Testosterone and Nutritional Supplementation in the Undernourished Elderly
Unknown status
Organon
Phase 3
2003-07-01
The purpose of this study is to determine what effect treatment for one year with
testosterone and a nutritional supplement, alone and combined, has on the adverse effects of
under-nutrition in community-dwelling older men and women.
The Effects of Testosterone and Nutritional Supplementation in the Undernourished Elderly
Unknown status
University of Adelaide
Phase 3
2003-07-01
The purpose of this study is to determine what effect treatment for one year with
testosterone and a nutritional supplement, alone and combined, has on the adverse effects of
under-nutrition in community-dwelling older men and women.
Male hypogonadism is a clinical situation characterized by a low serum testosterone level in
combination with a diversity of symptoms and signs such as reduced libido and vitality,
decreased muscle mass, increased fat mass and depression. Similar symptoms in combination
with subnormal testosterone levels are seen in some elderly men. Low testosterone levels are
associated with known cardiovascular risk factors, and men with diabetes and stroke have
lower testosterone levels than healthy men. Even though several publications have suggested
that testosterone treatment in hypogonadal men may have beneficial effects, it is still
uncertain if testosterone substitution in the aging man is indicated. Despite this
uncertainty the sale of testosterone has increased enormously the last few years.
We hypothesize that older men with subnormal testosterone levels have a varying degree of
dysfunction/symptoms both physically and mentally, and that these dysfunction/symptoms can be
improved with testosterone treatment.
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