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Last Updated: February 11, 2025

CLINICAL TRIALS PROFILE FOR TAZORAC


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All Clinical Trials for Tazorac

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00145106 ↗ Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris Completed Allergan Phase 4 2002-03-01 The purpose of the study is to compare the efficacy of three maintenance regimens (topical tazarotene, oral minocycline, or both) in sustaining improvement in acne.
NCT00145106 ↗ Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris Completed Jefferson Medical College of Thomas Jefferson University Phase 4 2002-03-01 The purpose of the study is to compare the efficacy of three maintenance regimens (topical tazarotene, oral minocycline, or both) in sustaining improvement in acne.
NCT00145106 ↗ Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris Completed Milton S. Hershey Medical Center Phase 4 2002-03-01 The purpose of the study is to compare the efficacy of three maintenance regimens (topical tazarotene, oral minocycline, or both) in sustaining improvement in acne.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Tazorac

Condition Name

Condition Name for Tazorac
Intervention Trials
Acne Vulgaris 11
Plaque Psoriasis 2
Hand-Foot Skin Reaction (HFSR) 1
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Condition MeSH

Condition MeSH for Tazorac
Intervention Trials
Acne Vulgaris 11
Psoriasis 3
Basal Cell Nevus Syndrome 2
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Clinical Trial Locations for Tazorac

Trials by Country

Trials by Country for Tazorac
Location Trials
United States 67
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Trials by US State

Trials by US State for Tazorac
Location Trials
California 7
Florida 6
Texas 6
Pennsylvania 5
New York 4
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Clinical Trial Progress for Tazorac

Clinical Trial Phase

Clinical Trial Phase for Tazorac
Clinical Trial Phase Trials
Phase 4 4
Phase 3 4
Phase 2 8
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Clinical Trial Status

Clinical Trial Status for Tazorac
Clinical Trial Phase Trials
Completed 19
Unknown status 1
Recruiting 1
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Clinical Trial Sponsors for Tazorac

Sponsor Name

Sponsor Name for Tazorac
Sponsor Trials
Bausch Health Americas, Inc. 3
Valeant Pharmaceuticals International, Inc. 3
Stiefel, a GSK Company 2
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Sponsor Type

Sponsor Type for Tazorac
Sponsor Trials
Industry 23
Other 14
NIH 2
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Tazorac (Tazarotene): Clinical Trials, Market Analysis, and Projections

Clinical Trials Overview

Tazorac, a topical retinoid containing tazarotene, has been extensively studied in various clinical trials to evaluate its efficacy and safety for different dermatological conditions.

Acne Treatment

Clinical trials have shown that Tazorac is highly effective in treating acne vulgaris. A study comparing the efficacy of 0.1% tazarotene gel applied either once or twice daily demonstrated significant improvements in both noninflammatory and inflammatory lesions. By week 12, patients treated with tazarotene gel showed a mean percentage reduction in noninflammatory lesions of 46% and 41%, and in inflammatory lesions of 38% and 34%, compared to a mere 2% and 9% reduction in the vehicle-only group[4].

Psoriasis Treatment

In clinical trials for psoriasis, Tazorac gel (0.05% and 0.1%) was evaluated in two controlled studies involving 439 subjects aged 14 to 87 years. The most common adverse events included pruritus, burning/stinging, erythema, worsening of psoriasis, irritation, and skin pain. Despite these side effects, the drug showed efficacy in managing psoriasis symptoms[1].

Safety and Adverse Effects

Clinical trials have highlighted the importance of sun protection while using Tazorac due to its potential for photosensitivity and risk of sunburn. Systemic absorption of tazarotene is generally low, with less than 1% of the applied dose absorbed without occlusion and approximately 5% with occlusion[1].

Market Analysis

Market Size and Growth

The global tazarotene market is projected to grow significantly over the next few years, driven by increasing concerns about skin health and appearance. The market size is expected to expand due to the rising prevalence of skin disorders such as acne, psoriasis, and sun damage. By 2030, the market is anticipated to see substantial growth, with key drivers including advancements in drug formulations, increased access to dermatological care, and the expanding beauty and wellness industry[2][5].

Market Segmentation

The tazarotene market is segmented by application (acne treatment, hyperpigmentation solutions, photodamage reversal), formulation type (creams, gels, foams), end users (hospitals, dermatology clinics, individual use), and distribution channels. The market penetration is strong in developed regions but also shows promising growth in emerging markets due to increasing affordability and accessibility[2].

Competitive Landscape

The competitive landscape of the tazarotene market is characterized by several key players, with market share analysis providing insights into their performance and challenges. Strategic partnerships, technological advancements, and innovative product developments are crucial for gaining a competitive edge. The market is also subject to Porter’s Five Forces analysis, which helps companies understand their competitive position and potential profitability[2].

Market Projections

Growth Drivers

Several factors are driving the growth of the tazarotene market:

  • Rising Prevalence of Skin Disorders: Increasing incidence of acne, psoriasis, and sun damage is driving the demand for effective dermatological treatments.
  • Advancements in Drug Formulations: Improvements in formulations such as creams, gels, and foams are enhancing patient compliance and efficacy.
  • Expanding Beauty and Wellness Industry: The growing demand for anti-aging treatments and skincare products is boosting the market.
  • Increased Access to Dermatological Care: Better healthcare infrastructure and access to dermatological services are contributing to market growth[2][5].

Market Opportunities

  • Personalized Medicine: The integration of AI and personalized treatment regimens could transform the market by offering tailored therapies.
  • Emerging Markets: There is a significant opportunity in emerging markets where affordability and accessibility are improving.
  • New Demographic Markets: Growing awareness of skincare among younger audiences presents a new demographic market for tazarotene drugs[2].

Market Challenges

  • High Costs and R&D Expenses: The expensive research and development process is a significant restraint.
  • Patient Compliance Issues: Side effects and the need for consistent application can affect patient compliance.
  • Regulatory and Safety Concerns: Ensuring safety and navigating regulatory hurdles are ongoing challenges[2].

Key Takeaways

  • Tazorac has shown significant efficacy in clinical trials for acne and psoriasis treatment.
  • The global tazarotene market is expected to grow substantially due to rising skin health concerns and advancements in drug formulations.
  • Key drivers include the expanding beauty and wellness industry, increased access to dermatological care, and emerging market opportunities.
  • Challenges such as high R&D costs, patient compliance issues, and regulatory concerns need to be addressed.

FAQs

What are the common applications of Tazorac?

Tazorac is commonly used for treating acne, psoriasis, hyperpigmentation, and photodamage.

What are the most frequent adverse effects of Tazorac?

The most frequent adverse effects include pruritus, burning/stinging, erythema, worsening of psoriasis, irritation, and skin pain.

How does Tazorac compare to other topical retinoids in acne treatment?

Tazorac has been shown to be more effective than other topical retinoids in reducing both noninflammatory and inflammatory acne lesions[4].

What are the key drivers of the tazarotene market growth?

Key drivers include the rising prevalence of skin disorders, advancements in drug formulations, increased access to dermatological care, and the expanding beauty and wellness industry.

What are the potential opportunities in the tazarotene market?

Opportunities lie in personalized medicine, emerging markets, and the growing awareness of skincare among younger audiences.

Sources

  1. FDA Label for TAZORAC Gel: AccessData FDA.
  2. Tazarotene Drugs Market Size & Share 2025-2030: 360iResearch.
  3. Changing Landscape of Plaque Psoriasis Treatment Market: DelveInsight.
  4. Successful Treatment of Acne Vulgaris Using a New Method: JAMA Dermatology.
  5. Global Tazarotene Market Insights, Forecast to 2029: GII Research.

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