CLINICAL TRIALS PROFILE FOR TYBOST
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All Clinical Trials for TYBOST
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT02503462 ↗ | Effect of Cobicistat Versus Ritonavir Boosting on the Brain Permeation of Darunavir in HIV-infected Individuals | Terminated | University Hospital, Basel, Switzerland | Phase 4 | 2015-07-01 | The purpose of this study is to assess whether a boosting by cobicistat results in similar concentrations of darunavir in the brain compared to a boosting by ritonavir. |
| NCT02565888 ↗ | A Drug-drug Interaction Study Between Daclatasvir and Atazanavir/Ritonavir or Atazanavir/Cobicistat | Completed | Radboud University | Phase 1 | 2015-11-01 | This study aims to provide the evidence that 150mg of cobicistat will have the same effect on the pharmacokinetics of daclatasvir 30mg QD as 100mg of ritonavir, when given together with atazanavir 300mg. |
| NCT03858491 ↗ | Pharmacokinetic Boosting of Osimertinib | Recruiting | The Netherlands Cancer Institute | Early Phase 1 | 2020-11-01 | The main objective of this study is to evaluate if systemic exposure of osimertinib (i.e. AUC) is increased when osimertinib is co-administered with cobicistat in patients with relatively low plasma trough concentration while receiving the standard osimertinib dose. |
| NCT03858491 ↗ | Pharmacokinetic Boosting of Osimertinib | Recruiting | ZonMw: The Netherlands Organisation for Health Research and Development | Early Phase 1 | 2020-11-01 | The main objective of this study is to evaluate if systemic exposure of osimertinib (i.e. AUC) is increased when osimertinib is co-administered with cobicistat in patients with relatively low plasma trough concentration while receiving the standard osimertinib dose. |
| NCT03858491 ↗ | Pharmacokinetic Boosting of Osimertinib | Recruiting | Academisch Ziekenhuis Maastricht | Early Phase 1 | 2020-11-01 | The main objective of this study is to evaluate if systemic exposure of osimertinib (i.e. AUC) is increased when osimertinib is co-administered with cobicistat in patients with relatively low plasma trough concentration while receiving the standard osimertinib dose. |
| NCT05236738 ↗ | A Study to Compare the Drug Levels of Atazanavir and Cobicistat Between the Coadministration of Age-Appropriate Mini-Tablet Formulations and the Coadministration of the Individual Reference Products in Healthy Adults Under Fed Conditions | Not yet recruiting | Bristol-Myers Squibb | Phase 1 | 2022-02-25 | The purpose of this study is to evaluate the drug absorption of atazanavir and cobicistat between the coadministration of the mini-tablet formulations in applesauce or chocolate pudding followed by water and the coadministration of atazanavir oral powder in applesauce and cobicistat oral tablet followed by water in healthy adult participants. |
| NCT05692570 ↗ | A Study of PBI-200 With Ritonavir or Cobicistat in Healthy Volunteers | Completed | Pyramid Biosciences | Phase 1 | 2022-09-09 | This is a drug-drug interaction study in volunteers to evaluate the effect of ritonavir or cobicistat on the pharmacokinetics (PK) of PBI-200. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
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