High Intensity Focused Ultrasound (HIFU) Ablation System Study
Suspended
ProRhythm, Inc.
Phase 3
2006-04-01
The purpose of this study is to determine if the HIFU Pulmonary Vein Ablation System is
effective in the treatment of paroxysmal Atrial Fibrillation compared to the control of best
medical therapy with FDA approved antiarrhythmic drugs.
AV Node Ablation and Pacemaker Therapy Compared to Drug Therapy for Atrial Fibrillation - Pilot Study
Terminated
Medtronic
Phase 3
2007-12-01
The purpose of this study is to determine whether early atrioventricular node (AVN) ablation
with pacing device therapy will reduce death and hospitalization when compared to the
conventional drug therapy in elderly patients with recurrent and symptomatic atrial
fibrillation (AF).
AV Node Ablation and Pacemaker Therapy Compared to Drug Therapy for Atrial Fibrillation - Pilot Study
Terminated
Mayo Clinic
Phase 3
2007-12-01
The purpose of this study is to determine whether early atrioventricular node (AVN) ablation
with pacing device therapy will reduce death and hospitalization when compared to the
conventional drug therapy in elderly patients with recurrent and symptomatic atrial
fibrillation (AF).
Ability of Late Sodium or Calcium Current Block to Balance the ECG Effects of Potassium Current Block
Completed
Spaulding Clinical Research LLC
Phase 1
2014-05-01
The primary objective of this research study is to test the hypothesis that late sodium
current blocking drugs (mexiletine or lidocaine) can attenuate the effect of hERG potassium
channel blocking drugs (dofetilide) on ventricular repolarization (QTc) by shortening early
repolarization (J-Tpeakc). The secondary object is to assess the ability of calcium channel
block (diltiazem) to reduce the QTc prolongation associated with hERG block (moxifloxacin).
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