Last Updated: May 21, 2026

CLINICAL TRIALS PROFILE FOR TIAZAC


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All Clinical Trials for TIAZAC

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00713011 ↗ Adalat XL vs Diltiazem on Proteinuria and Blood Pressure in Hypertensive Diabetic Patients Withdrawn Bayer Phase 3 2008-11-01 The study consists of a 12 week run-in period when all subjects are stabilized on a single dose of Avalide (300 mg/12.5 mg or 300mg/25mg dose) per day. After this 12 week run-in ends, subjects will be randomly assigned to start the addition of either Adalat XL or Tiazac XC for 18 weeks of treatment. Subjects will have a 1 in 2 chance of receiving the study drug Adalat XL and a 1 in 2 chance of receiving the drug Tiazac XC. An end of treatment visit will be done 18 weeks after start of study drug. The expected duration of the study is 30 weeks. The purpose of this study is to compare the change in proteinuria, through a urine test, while taking study drug until high blood pressure (BP) is reduced to near normal levels in study subjects with diabetic nephropathy and hypertension.
NCT04790331 ↗ Efficacy of Oral Verapamil and Oral Diltiazim on Reduction of Intraoperative Bleeding During Endoscopic Sinus Surgery Under General Anesthesia Not yet recruiting Assiut University Early Phase 1 2021-03-01 To study the effect of addition of oral verapamil or Diltiazim to general anaesthesia on the Intraoperative haemodynamics : heart rate(HR), noninvasive blood pressure(NIBP), mean arterial blood pressure(MAP), and the blood loss during endoscopic sinus surgery.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for TIAZAC

Condition Name

Condition Name for TIAZAC
Intervention Trials
Hypertension 1
Verapamil 1
Diabetic Nephropathies 1
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Condition MeSH

Condition MeSH for TIAZAC
Intervention Trials
Blood Loss, Surgical 1
Proteinuria 1
Hypertension 1
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Clinical Trial Progress for TIAZAC

Clinical Trial Phase

Clinical Trial Phase for TIAZAC
Clinical Trial Phase Trials
Phase 3 1
Early Phase 1 1
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Clinical Trial Status

Clinical Trial Status for TIAZAC
Clinical Trial Phase Trials
Withdrawn 1
Not yet recruiting 1
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Clinical Trial Sponsors for TIAZAC

Sponsor Name

Sponsor Name for TIAZAC
Sponsor Trials
Bayer 1
Assiut University 1
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Sponsor Type

Sponsor Type for TIAZAC
Sponsor Trials
Other 1
Industry 1
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TIAZAC Clinical Trials Update, Market Analysis, and Projection

Last updated: May 7, 2026

What is TIAZAC and what product scope drives the market?

TIAZAC is a branded sustained-release diltiazem product. In practice, the commercial narrative for TIAZAC is shaped by (i) continued demand for once-daily diltiazem therapy in hypertension and angina and (ii) competitive pressure from generic extended-release diltiazem formulations and channel pricing. The drug’s market profile is therefore dominated by: ongoing prescription volumes, payer formulary placement, and effective pricing after generic entry.

What clinical trial activity exists for TIAZAC?

No complete, citation-backed clinical trials update for TIAZAC (including trial identifiers, phase, enrollment, endpoints, and readouts) can be produced from the information available in this conversation. A trials update requires verifiable specifics from registries or published sources (e.g., ClinicalTrials.gov NCT numbers, EudraCT IDs, sponsor, status history, and results).

How large is the market opportunity and what are the key demand drivers?

A credible market analysis and forward projection for TIAZAC requires current sales baselines, segment definitions (branded vs generic diltiazem ER), geography, and payer and channel dynamics, which are not provided here. Without a sourceable market baseline and geography, any numeric projection would be non-actionable.

What drives uptake and retention for TIAZAC in the real world?

TIAZAC’s commercial performance typically depends on:

  • Formulary access for diltiazem ER products (tier placement and prior authorization rules)
  • Generic substitution intensity and pharmacy incentives
  • Persistence of chronic antihypertensive and antianginal therapy (switching patterns among diltiazem ER brands and authorized generics)
  • Safety and tolerability perceptions vs alternative calcium channel blockers

What is the projection framework for TIAZAC?

A proper projection needs:

  • Historical sales (at least 3 to 5 years) by market and channel
  • Expected competitive actions (generic or authorized generic timing, label expansions, brand consolidation)
  • Country-level reimbursement trajectory and copay dynamics
  • Patent and exclusivity status effects on pricing power and gross-to-net

Those inputs are not available in the current context.

What is the investment-grade bottom line for 2026 to 2031?

A projection for 2026 to 2031 must be anchored to a sales baseline and explicit assumptions on erosion, pricing, and volume retention. Those inputs cannot be grounded here.


Key Takeaways

  • A clinical trials update for TIAZAC requires source-backed trial identifiers and status/readout data; none is available in the current information set.
  • Market sizing and numeric projections require historical sales baselines and competitive timeline data; none is available here.
  • The only defensible, decision-relevant points that can be stated without unverifiable assumptions are the market drivers: formulary access, generic substitution intensity, and chronic therapy persistence.

FAQs

  1. Is TIAZAC still under meaningful exclusivity that would support premium pricing?
    Exclusivity and patent status effects cannot be stated here without verifiable, citation-backed legal and regulatory timelines.

  2. What phase of development would matter most for a diltiazem ER brand like TIAZAC?
    For existing marketed products, commercially relevant updates usually come from label-expansion studies, bioequivalence/regulatory filings, and outcomes studies; a specific TIAZAC update requires registry sources.

  3. How does generic substitution typically affect branded extended-release diltiazem products?
    It compresses net pricing through channel incentives and formulary tiering, with volume shifting toward lowest-cost alternatives.

  4. Which endpoints drive payer decisions for calcium channel blocker chronic therapies?
    Payer decisions usually rely on comparative effectiveness, tolerability, and adherence impacts, with safety signals influencing formulary positioning.

  5. Can a forecast be created without a sales baseline?
    No. Investment-grade forecasts require historical sales, competitive actions, and explicit erosion assumptions.


References

  1. [No cited sources were provided in the conversation.]

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