DrugPatentWatch Database Preview

CLINICAL TRIALS PROFILE FOR SUDAFED 12 HOUR

« Back to Dashboard

All Clinical Trials for Sudafed 12 Hour

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00002149	Acupuncture and Herbal Treatment of Chronic HIV Sinusitis	Completed	Immune Enhancement Project	N/A	1969-12-31	To compare Traditional Chinese Medicine versus standard antibiotic therapy consisting of pseudoephedrine ( Sudafed ) plus amoxicillin / clavulanate potassium combination ( Augmentin ) in reducing symptoms and recurrence of acute HIV-related sinusitis. Chronic sinusitis in HIV-infected individuals is a recurrent and persistent infection with potentially serious complications: it can exacerbate pulmonary disease, cause recurrences of life-threatening sepsis, and progress to central nervous system involvement. Symptoms of sinusitis in HIV patients are often refractory to aggressive Western medical management, and antibiotic intolerance can occur. Traditional Chinese Medicine consisting of acupuncture and herbal treatment may provide a low-risk, low-cost alternative to conventional antibiotic therapy.
NCT00179023	The Autonomic Nervous System and Obesity	Active, not recruiting	Vanderbilt University Medical Center	Phase 1/Phase 2	2003-04-01	In its simplest terms, obesity is the results of a positive balance between food intake and energy expenditure (EE). I.e., we take in more energy, in the form of food, than we expend, e.g., by exercise. In our sedentary society, resting EE accounts for most of total energy expenditure. The sympathetic nervous system (SNS, the one that produces adrenaline) is thought to contribute to resting EE. This conclusion is based on experiments where resting EE is decreased by beta-blockers, high blood pressure medicines that block only one aspect of the sympathetic nervous system. The investigators propose to use a different approach, by using a medication called trimethaphan that produces transient withdrawal of the autonomic nervous system. The investigators will then compare the measured resting EE before and after SNS withdraw and quantify the degree of contribution to the resting EE by the SNS and delineate differences between healthy normal, healthy obese, and patients with autonomic dysfunctions.
NCT00223691	Treatment of Orthostatic Hypotension in Autonomic Failure	Recruiting	Vanderbilt University Medical Center	Phase 3	2002-03-01	The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function. There are several diseases characterized by abnormal function of the autonomic nervous system. Medications can also alter autonomic function. Impairment of the autonomic nervous system by diseases or drugs may lead to several symptoms, including blood pressure problems (e.g., high blood pressure lying down and low blood pressure on standing), sweating abnormalities, constipation or diarrhea and sexual dysfunction. Because treatment options for these patients are limited. We propose to study patients autonomic failure and low blood pressure upon standing and determine the cause of their disease by history and examination and their response to autonomic testing which have already been standardized in our laboratory. Based on their possible cause, we will tests different medications that may alleviate their symptoms.
NCT00377403	Treatment of Acute Sinusitis	Completed	National Institute of Allergy and Infectious Diseases (NIAID)	Phase 4	2006-10-01	This study will compare the symptom relief provided by 5 cold medicines versus the symptom relief provided by the same 5 cold medicines plus the antibiotic, amoxicillin, in people who have sinus infections. Treatment with amoxicillin may be more effective than treatment with cold medicines alone. Two hundred adult volunteers, aged 18 to 70 years old, with sinus infections will participate in this study for 28 days. Volunteers will receive a 10-day course of either amoxicillin or placebo (substance containing no medication). In addition, all volunteers will receive pain medication, a chest decongestant, nasal decongestants, and cough medicine as needed. Volunteers will be interviewed by telephone on days 0, 3, 7, 10, and 28 following the start of treatment. The study will look at quality of life factors such as change in functional status (ability to perform daily activities) and symptoms, recurrence of the infection, satisfaction with care, and the direct costs of treatment.
NCT00377403	Treatment of Acute Sinusitis	Completed	Washington University School of Medicine	Phase 4	2006-10-01	This study will compare the symptom relief provided by 5 cold medicines versus the symptom relief provided by the same 5 cold medicines plus the antibiotic, amoxicillin, in people who have sinus infections. Treatment with amoxicillin may be more effective than treatment with cold medicines alone. Two hundred adult volunteers, aged 18 to 70 years old, with sinus infections will participate in this study for 28 days. Volunteers will receive a 10-day course of either amoxicillin or placebo (substance containing no medication). In addition, all volunteers will receive pain medication, a chest decongestant, nasal decongestants, and cough medicine as needed. Volunteers will be interviewed by telephone on days 0, 3, 7, 10, and 28 following the start of treatment. The study will look at quality of life factors such as change in functional status (ability to perform daily activities) and symptoms, recurrence of the infection, satisfaction with care, and the direct costs of treatment.
NCT00673062	Study of the Effect of SCH 900538 on Congestion in Subjects With Seasonal Allergic Rhinitis (Study P05031)(COMPLETED)	Completed	Merck Sharp & Dohme Corp.	Phase 2	2008-05-01	This study is to evaluate the effectiveness of a new drug on congestion in subjects with seasonal allergic rhinitis. This effect will be compared to placebo and to the decongestant, pseudoephedrine.
NCT00779805	Bioequivalence Study of Pseudoephedrine HCl 120 mg ER Tablets Under Fed Conditions	Completed	Ranbaxy Laboratories Limited	N/A	2004-06-01	The objective of the study was to compare the single dose oral bioavailability of Pseudoephedrine hydrochloride 120 mg ER tablets of Ranbaxy with Sudafed 120 mg ER tablets of Pfizer Consumer Health Care in healthy, adult, human subjects under fed conditions.

Clinical Trial Conditions for Sudafed 12 Hour

Condition Name

Condition Name for Sudafed 12 Hour
Intervention	Trials
Healthy	2
Shy-Drager Syndrome	2
OBESITY	1
Autonomic Failure	1

Condition MeSH

Condition MeSH for Sudafed 12 Hour
Intervention	Trials
Pure Autonomic Failure	3
Multiple System Atrophy	2
Sinusitis	2
Shy-Drager Syndrome	2

Clinical Trial Locations for Sudafed 12 Hour

Trials by Country

Trials by Country for Sudafed 12 Hour
Location	Trials
United States	6
Canada	1
India	1

Trials by US State

Trials by US State for Sudafed 12 Hour
Location	Trials
Tennessee	3
Pennsylvania	1
Missouri	1
California	1

Clinical Trial Progress for Sudafed 12 Hour

Clinical Trial Phase

Clinical Trial Phase for Sudafed 12 Hour
Clinical Trial Phase	Trials
Phase 4	1
Phase 3	1
Phase 2	1

Clinical Trial Status

Clinical Trial Status for Sudafed 12 Hour
Clinical Trial Phase	Trials
Completed	5
Recruiting	3
Active, not recruiting	1

Clinical Trial Sponsors for Sudafed 12 Hour

Sponsor Name

Sponsor Name for Sudafed 12 Hour
Sponsor	Trials
Vanderbilt University Medical Center	2
Ranbaxy Laboratories Limited	2
Merck Sharp & Dohme Corp.	1

Sponsor Type

Sponsor Type for Sudafed 12 Hour
Sponsor	Trials
Other	6
NIH	4
Industry	3