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Last Updated: January 20, 2020

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CLINICAL TRIALS PROFILE FOR SACUBITRIL; VALSARTAN

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All Clinical Trials for Sacubitril; Valsartan

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02554890 comParIson Of Sacubitril/valsartaN Versus Enalapril on Effect on ntpRo-bnp in Patients Stabilized From an Acute Heart Failure Episode Recruiting Novartis Pharmaceuticals Phase 4 2016-04-01 The purpose of this study is to assess the effect of in-hospital initiation of sacubitril/valsartan (LCZ696) vs. enalapril on time averaged proportional change in NT-proBNP in patients who have been stabilized following hospitalization for acute decompensated heart failure (ADHF) and reduced ejection fraction (left ventricular ejection fraction (LVEF) ≤ 40%).
NCT02636283 Use of Entresto Sacubitril/Valsartan for the Treatment of Peripheral Arterial Disease Not yet recruiting American Heart Association Phase 2 2017-03-01 This study proposes the use of Entresto (sacubitril/valsartan) to test the effects on pain free walking duration on patients with peripheral arterial disease, a condition caused by decreased blood flow to the muscles in the legs.
NCT02636283 Use of Entresto Sacubitril/Valsartan for the Treatment of Peripheral Arterial Disease Not yet recruiting University of Minnesota - Clinical and Translational Science Institute Phase 2 2017-03-01 This study proposes the use of Entresto (sacubitril/valsartan) to test the effects on pain free walking duration on patients with peripheral arterial disease, a condition caused by decreased blood flow to the muscles in the legs.
NCT02682719 ARNI in Asymptomatic Patients With Elevated Natriuretic Peptide and Elevated Left Atrial Volume Index eLEvation Recruiting Novartis Ireland Ltd Phase 2 2015-12-01 The purpose of this study is to determine whether LCZ696 (valsartan/sacubitril) is safe and has beneficial effects on the heart and blood vessels in patients with high blood pressure and/or diabetes or other risk factors for developing heart failure (elevated levels of natriuretic peptide and elevated left atrial volume index). Patients will be randomized to receive LCZ696 or valsartan (and matching placebo) for 18 months to assess the impact on left ventricular diastolic function.
NCT02682719 ARNI in Asymptomatic Patients With Elevated Natriuretic Peptide and Elevated Left Atrial Volume Index eLEvation Recruiting The Heartbeat Trust Phase 2 2015-12-01 The purpose of this study is to determine whether LCZ696 (valsartan/sacubitril) is safe and has beneficial effects on the heart and blood vessels in patients with high blood pressure and/or diabetes or other risk factors for developing heart failure (elevated levels of natriuretic peptide and elevated left atrial volume index). Patients will be randomized to receive LCZ696 or valsartan (and matching placebo) for 18 months to assess the impact on left ventricular diastolic function.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Sacubitril; Valsartan

Condition Name

Condition Name for Sacubitril; Valsartan
Intervention Trials
Heart Failure 15
Heart Failure With Preserved Ejection Fraction 3
Diastolic Dysfunction 2
Hypertension 2
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Condition MeSH

Condition MeSH for Sacubitril; Valsartan
Intervention Trials
Heart Failure 33
Myocardial Infarction 3
Hypertrophy 3
Prediabetic State 2
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Clinical Trial Locations for Sacubitril; Valsartan

Trials by Country

Trials by Country for Sacubitril; Valsartan
Location Trials
United States 27
Canada 8
China 2
Ireland 1
Brazil 1
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Trials by US State

Trials by US State for Sacubitril; Valsartan
Location Trials
Texas 3
Pennsylvania 2
Minnesota 2
Illinois 2
Ohio 2
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Clinical Trial Progress for Sacubitril; Valsartan

Clinical Trial Phase

Clinical Trial Phase for Sacubitril; Valsartan
Clinical Trial Phase Trials
Phase 4 20
Phase 3 7
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Sacubitril; Valsartan
Clinical Trial Phase Trials
Not yet recruiting 26
Recruiting 18
Withdrawn 1
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Clinical Trial Sponsors for Sacubitril; Valsartan

Sponsor Name

Sponsor Name for Sacubitril; Valsartan
Sponsor Trials
Novartis Pharmaceuticals 15
Brigham and Women's Hospital 2
Vanderbilt University Medical Center 2
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Sponsor Type

Sponsor Type for Sacubitril; Valsartan
Sponsor Trials
Other 47
Industry 17
NIH 3
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