Enzalutamide Versus Standard Androgen Deprivation Therapy for the Treatment Hormone Sensitive Prostate Cancer
Unknown status
University of Colorado, Denver
Phase 2
2015-11-11
This randomized phase II trial compares enzalutamide with standard androgen deprivation
therapy in reducing incidence of metabolic syndrome in patients with prostate cancer that has
spread to other places in the body. Metabolic syndrome is defined as changes in cholesterol,
blood pressure, circulating sugar levels, and body weight. Previous studies have shown that
patients with prostate cancer, who have been treated with standard medical therapy that
lowers testosterone levels, have an increased risk of these changes. Hormone therapy using
enzalutamide may fight prostate cancer by blocking the use of testosterone by the tumor cells
instead of lowering testosterone levels. It is not yet known whether prostate cancer patients
who receive enzalutamide will have reduced incidence of metabolic syndrome than patients who
receive standard androgen deprivation therapy.
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
Recruiting
National Cancer Institute (NCI)
Phase 3
2018-09-17
This phase III trial studies how well standard systemic therapy with or without definitive
treatment (prostate removal surgery or radiation therapy) works in treating participants with
prostate cancer that has spread to other places in the body. Addition of prostate removal
surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the
chance of the cancer growing or spreading.
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
Recruiting
Southwest Oncology Group
Phase 3
2018-09-17
This phase III trial studies how well standard systemic therapy with or without definitive
treatment (prostate removal surgery or radiation therapy) works in treating participants with
prostate cancer that has spread to other places in the body. Addition of prostate removal
surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the
chance of the cancer growing or spreading.
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