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Last Updated: March 29, 2024

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CLINICAL TRIALS PROFILE FOR SPRAVATO


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All Clinical Trials for SPRAVATO

Trial ID Title Status Sponsor Phase Start Date Summary
NCT05268497 ↗ A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant Depression Not yet recruiting Janssen Research & Development, LLC Phase 1 2022-03-14 The purpose of this study is to explore feasibility of combining clinician-directed cognitive behavioral therapy (CBT) supplemented with the Mindset app with esketamine therapy in participants with Treatment-resistant Depression.
NCT05323019 ↗ Repeated Intranasal Esketamine Plus Almond Therapy in Patients With Treatment Resistant Depression Not yet recruiting Zylorion Health Phase 2 2022-05-01 To examine the efficacy of Almond Therapy compared to Treatment as Usual when used in addition to an approved version of intranasal esketamine.
NCT05554627 ↗ VA Aripiprazole vs Esketamine for Treatment Resistant Depression Not yet recruiting VA Office of Research and Development Phase 4 2023-03-01 This is an open-label, parallel-group, randomized clinical trial of up to 6 months treatment of adjunctive intranasal (IN) esketamine (ESK) vs. adjunctive aripiprazole (ARI) in Veterans with unipolar Treatment Resistant Depression (TRD). This study will assess the efficacy, safety, and acceptability of adjunctive IN ESK in comparison to ARI, one of the best studied and most widely used adjunctive therapies for TRD. The primary hypothesis is that participants receiving adjunctive IN ESK will be significantly more likely to achieve remission after six weeks of treatment as compared to those who receive adjunctive ARI. Depressive symptoms will be assessed by central raters (CR), blinded to treatment assignment, using the clinician rated version of the Quick Inventory of Depressive Symptomatology (QIDS-C16), a well-validated tool that is commonly used and is easily translated across other depression inventory scales. The study is powered to detect an absolute difference in remission rates of 10%, or larger, at 6 weeks. Additional outcomes of interest include symptom reduction across 6 months of randomized therapy, side effects and other tolerability indices, attrition rates and measures of quality of life and cost-effectiveness.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for SPRAVATO

Condition Name

Condition Name for SPRAVATO
Intervention Trials
Depression 1
Depressive Disorder, Major 1
Treatment Resistant Major Depressive Disorder 1
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Condition MeSH

Condition MeSH for SPRAVATO
Intervention Trials
Depressive Disorder 3
Depressive Disorder, Major 2
Depression 2
Depressive Disorder, Treatment-Resistant 1
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Clinical Trial Locations for SPRAVATO

Trials by Country

Trials by Country for SPRAVATO
Location Trials
United States 25
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Trials by US State

Trials by US State for SPRAVATO
Location Trials
Ohio 2
Illinois 2
Connecticut 2
Michigan 1
Alabama 1
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Clinical Trial Progress for SPRAVATO

Clinical Trial Phase

Clinical Trial Phase for SPRAVATO
Clinical Trial Phase Trials
Phase 4 1
Phase 2 1
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for SPRAVATO
Clinical Trial Phase Trials
Not yet recruiting 3
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Clinical Trial Sponsors for SPRAVATO

Sponsor Name

Sponsor Name for SPRAVATO
Sponsor Trials
VA Office of Research and Development 1
Janssen Research & Development, LLC 1
Zylorion Health 1
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Sponsor Type

Sponsor Type for SPRAVATO
Sponsor Trials
Industry 2
U.S. Fed 1
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