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Generated: December 16, 2018

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CLINICAL TRIALS PROFILE FOR RUBRACA

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Clinical Trials for Rubraca

Trial ID Title Status Sponsor Phase Summary
NCT02986100 Absorption, Metabolism, and Excretion Following a Single Oral Dose of [14C]-Rucaparib Active, not recruiting Clovis Oncology, Inc. Phase 1 The purpose of this study is to characterize the mass balance, absorption, metabolism, and elimination pathways of orally administered [14C] rucaparib followed by cycle by cycle treatment with rucaparib continuing until disease progression or other reason for discontinuation
NCT03318445 Rucaparib and Irinotecan in Cancers With Mutations in DNA Repair Not yet recruiting Clovis Oncology, Inc. Phase 1 This is an open label, non-randomized, dose escalation and expansion Phase Ib trial to evaluate the safety and recommended phase II dose of the combination of irinotecan and rucaparib.
NCT03318445 Rucaparib and Irinotecan in Cancers With Mutations in DNA Repair Not yet recruiting Pamela Munster Phase 1 This is an open label, non-randomized, dose escalation and expansion Phase Ib trial to evaluate the safety and recommended phase II dose of the combination of irinotecan and rucaparib.
NCT03442556 Docetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency Not yet recruiting National Cancer Institute (NCI) Phase 2 This phase II trial studies how well docetaxel, carboplatin, and rucaparib camsylate work in treating patients with castration resistant prostate cancer with homologous recombination deoxyribonucleic acid (DNA) repair deficiency that has spread to other places in the body. Drugs used in chemotherapy, such as docetaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Rucaparib camsylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving induction docetaxel and carboplatin followed by maintenance rucaparib camsylate may work better in treating patients with castration resistant prostate cancer.
NCT03442556 Docetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency Not yet recruiting University of Washington Phase 2 This phase II trial studies how well docetaxel, carboplatin, and rucaparib camsylate work in treating patients with castration resistant prostate cancer with homologous recombination deoxyribonucleic acid (DNA) repair deficiency that has spread to other places in the body. Drugs used in chemotherapy, such as docetaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Rucaparib camsylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving induction docetaxel and carboplatin followed by maintenance rucaparib camsylate may work better in treating patients with castration resistant prostate cancer.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Rubraca

Condition Name

Condition Name for Rubraca
Intervention Trials
BRCA2 Gene Mutation 2
BRCA1 Gene Mutation 2
Prostate Carcinoma Metastatic in the Bone 1
Castration-Resistant Prostate Carcinoma 1
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Condition MeSH

Condition MeSH for Rubraca
Intervention Trials
Fallopian Tube Neoplasms 2
Prostatic Neoplasms 2
Carcinoma 2
Ovarian Neoplasms 2
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Clinical Trial Locations for Rubraca

Trials by Country

Trials by Country for Rubraca
Location Trials
United States 19
Poland 1
Australia 1
Czechia 1
United Kingdom 1
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Trials by US State

Trials by US State for Rubraca
Location Trials
Ohio 2
Maryland 1
Washington 1
Arizona 1
Colorado 1
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Clinical Trial Progress for Rubraca

Clinical Trial Phase

Clinical Trial Phase for Rubraca
Clinical Trial Phase Trials
Phase 3 1
Phase 2 2
Phase 1 4
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Clinical Trial Status

Clinical Trial Status for Rubraca
Clinical Trial Phase Trials
Recruiting 4
Not yet recruiting 2
Active, not recruiting 1
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Clinical Trial Sponsors for Rubraca

Sponsor Name

Sponsor Name for Rubraca
Sponsor Trials
Clovis Oncology, Inc. 6
Foundation Medicine 1
European Network of Gynaecological Oncological Trial Groups (ENGOT) 1
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Sponsor Type

Sponsor Type for Rubraca
Sponsor Trials
Industry 9
Other 6
NIH 1
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Serving hundreds of leading biopharmaceutical companies globally:

Moodys
Medtronic
Daiichi Sankyo
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Baxter
Federal Trade Commission
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Cipla
Johnson and Johnson

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