Intravenous Azithromycin Plus Intravenous Ceftriaxone Followed by Oral Azithromycin With Intravenous Levofloxacin Followed by Oral Levofloxacin for the Treatment of Moderate to Severely Ill Hospitalized Patients With Community Acquired Pneumonia
A trial in which patients over 18 years of age who are hospitalized with community acquired
pneumonia and are otherwise eligible for entry into the study are randomly selected to
receive one of two treatment regimens. After written informed consent is obtained, patients
will receive one of the following two treatment regimens: 1) intravenous administration of
azithromycin and ceftriaxone followed by azithromycin tablets, or 2) intravenous
administration of levofloxacin followed by levofloxacin tablets. At least four study visits
are normally conducted up to approximately one month after starting therapy. The objective of
this study is to compare the safety and efficacy of the two treatment regimens.
Brain Imaging and Retreatment Study of Persistent Lyme Disease
National Institute of Neurological Disorders and Stroke (NINDS)
The purpose of this study is to determine whether patients with persistent memory problems
after Lyme disease benefit from an additional longer course of IV antibiotic therapy; to use
modern brain imaging technology to determine whether the problem in the central nervous
system is primarily one of poor blood flow or one of impaired nerve cell functioning; and to
try to identify biological markers prior to treatment that will identify patients who are
more or less likely to respond to the study treatment.
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