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Last Updated: November 21, 2019

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CLINICAL TRIALS PROFILE FOR RIFAMYCIN

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All Clinical Trials for Rifamycin

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000641 A Phase II/III Trial of Rifampin, Ciprofloxacin, Clofazimine, Ethambutol, and Amikacin in the Treatment of Disseminated Mycobacterium Avium Infection in HIV-Infected Individuals. Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 1969-12-31 To compare the effectiveness and toxicity of two combination drug treatment programs for the treatment of disseminated Mycobacterium avium infection in HIV seropositive patients. [Per 03/06/92 amendment: to evaluate the efficacy of azithromycin when given in conjunction with either ethambutol or clofazimine as maintenance therapy.] Disseminated M. avium infection is the most common systemic bacterial infection complicating AIDS in the United States. The prognosis of patients with disseminated M. avium is extremely poor, particularly when it follows other opportunistic infections or is associated with anemia. Test tube studies and clinical data indicate that the best treatment program may include clofazimine, ethambutol, a rifamycin derivative, and ciprofloxacin. Test tube and animal studies indicate that amikacin is a bactericidal (bacteria destroying) drug that works better when used with ciprofloxacin. Its role in treatment programs is a key issue because of toxicity and because it must be administered parenterally (by injection or intravenously).
NCT00000877 Study of How Indinavir (an Anti-HIV Drug) and Rifabutin (a Drug Used to Treat MAC, an HIV-Associated Disease) Interact in HIV-Positive and HIV-Negative Adults Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 1969-12-31 The purpose of this study is to evaluate the safety of giving indinavir and rifabutin at the same time (simultaneously) vs 4 hours apart (staggered) to HIV-positive and HIV-negative adults. It is important to determine which medications for HIV-associated diseases, such as Mycobacterium avium complex (MAC) disease, can be given safely and effectively with anti-HIV drugs. Indinavir and rifabutin have been given simultaneously in the past with good results. This study seeks to examine if staggering the doses will make the 2 drugs more effective. HIV-negative volunteers are used in this study to examine the effect of rifabutin on indinavir and the effect of staggered rifabutin doses. The effect of rifabutin on the drug activity of indinavir is evaluated in HIV-positive patients.
NCT00001023 The Safety and Effectiveness of Rifabutin, Combined With Clarithromycin or Azithromycin, in HIV-Infected Patients Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A 1969-12-31 PER 03/10/94 AMENDMENT: PART B. To determine whether there is an effect on plasma drug levels of azithromycin and rifabutin as measured by changes in the plasma concentration-time curve (AUC) when these drugs are taken concomitantly. ORIGINAL PRIMARY: To gain preliminary information about the safety and tolerance of clarithromycin and azithromycin in combination with rifabutin (three potential agents against Mycobacterium avium-intracellulare) in HIV-infected patients with CD4 counts < 200 cells/mm3. ORIGINAL SECONDARY: To determine whether there is an effect on the pharmacokinetics of the macrolide antibiotics or rifabutin when these drugs are taken concomitantly. To monitor the effect of rifabutin therapy on dapsone serum levels in patients taking dapsone for PCP prophylaxis. To monitor the effect of macrolide/rifabutin combination therapies on AZT or ddI serum levels. Two new macrolide antibiotics, clarithromycin and azithromycin, and rifabutin (a rifamycin derivative) have all demonstrated in vitro and in vivo activity against Mycobacterium avium-intracellulare, a common systemic bacterial infection complicating AIDS. Further information is needed, however, regarding the clinical and pharmacokinetic interaction of these drugs used in combination.
NCT00001058 A Comparison of Three Drug Combinations Containing Clarithromycin in the Treatment of Mycobacterium Avium Complex (MAC) Disease in Patients With AIDS Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 1969-12-31 To compare the efficacy and safety of clarithromycin combined with rifabutin, ethambutol, or both in the treatment of disseminated Mycobacterium avium Complex (MAC) disease in persons with AIDS, including individuals who have or have not received prior MAC prophylaxis. It is believed that effective therapy for MAC disease in patients with AIDS requires combinations of two or more antimycobacterial agents in order to overcome drug resistance and the unfavorable influence of the profound immunosuppression associated with AIDS. Data suggest that clarithromycin may have substantial activity in two- or three-drug combination regimens with clofazimine, rifamycin derivatives, ethambutol, or the 4-quinolones.
NCT00023361 TBTC Study 23: Treatment of HIV-Related Tuberculosis Using a Rifabutin-Based Regimen Completed VA Office of Research and Development N/A 1999-02-01 Primary objective: To determine the rate of confirmed treatment failure and relapse with an intermittent rifabutin-based regimen for the treatment of isoniazid and rifamycin-susceptible HIV-related tuberculosis (TB).
NCT00023361 TBTC Study 23: Treatment of HIV-Related Tuberculosis Using a Rifabutin-Based Regimen Completed Centers for Disease Control and Prevention N/A 1999-02-01 Primary objective: To determine the rate of confirmed treatment failure and relapse with an intermittent rifabutin-based regimen for the treatment of isoniazid and rifamycin-susceptible HIV-related tuberculosis (TB).
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Rifamycin

Condition Name

Condition Name for Rifamycin
Intervention Trials
HIV Infections 5
Tuberculosis 4
Traveler's Diarrhea 4
Mycobacterium Avium-intracellulare Infection 3
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Condition MeSH

Condition MeSH for Rifamycin
Intervention Trials
HIV Infections 8
Tuberculosis 7
Diarrhea 5
Infection 5
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Clinical Trial Locations for Rifamycin

Trials by Country

Trials by Country for Rifamycin
Location Trials
United States 65
Canada 3
Mexico 3
Guatemala 2
South Africa 2
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Trials by US State

Trials by US State for Rifamycin
Location Trials
Maryland 8
North Carolina 6
California 6
Colorado 4
Washington 4
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Clinical Trial Progress for Rifamycin

Clinical Trial Phase

Clinical Trial Phase for Rifamycin
Clinical Trial Phase Trials
Phase 3 7
Phase 2/Phase 3 2
Phase 2 9
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Clinical Trial Status

Clinical Trial Status for Rifamycin
Clinical Trial Phase Trials
Completed 12
Not yet recruiting 7
Recruiting 6
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Clinical Trial Sponsors for Rifamycin

Sponsor Name

Sponsor Name for Rifamycin
Sponsor Trials
National Institute of Allergy and Infectious Diseases (NIAID) 5
Cosmo Technologies Ltd 4
Centers for Disease Control and Prevention 3
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Sponsor Type

Sponsor Type for Rifamycin
Sponsor Trials
Other 19
Industry 14
NIH 8
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