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Last Updated: May 26, 2022

CLINICAL TRIALS PROFILE FOR RIFAMPIN


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All Clinical Trials for Rifampin

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000636 ↗ Prophylaxis Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A 1969-12-31 To evaluate and compare the effectiveness of a 2-month regimen of rifampin and pyrazinamide versus a 1-year course of isoniazid (INH) to prevent the development of tuberculosis in patients who are coinfected with HIV and latent Mycobacterium tuberculosis (MTb). Current guidelines recommend 6 to 12 months of treatment with INH for purified protein derivative (PPD)-positive individuals. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to INH-resistant organisms. Studies suggest that two or three months of rifampin and pyrazinamide may be more effective than longer courses of INH. A two-month prevention course should help to increase compliance. In addition, the use of two drugs (rifampin and pyrazinamide) may help overcome problems with drug resistance.
NCT00000638 ↗ Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection Completed Hoechst Marion Roussel N/A 1969-12-31 To evaluate and compare the safety and effectiveness of a one-year course of isoniazid (INH) versus a two-month course of rifampin plus pyrazinamide for the prevention of reactivation tuberculosis in individuals infected with both HIV and latent (inactive) Mycobacterium tuberculosis. Current guidelines from the American Thoracic Society and the Centers for Disease Control recommend 6 to 12 months of INH for PPD (purified protein derivative)-positive individuals. Although the effectiveness of this treatment is not known for HIV-infected individuals, several studies using INH to prevent tuberculosis in presumably normal hosts have shown 60 to 80 percent effectiveness. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to tuberculosis organisms being resistant to INH. A two-month preventive treatment plan should help in increasing compliance. In addition, the use of two drugs (rifampin / pyrazinamide) may help overcome problems with drug resistance. If this study shows equal or greater effectiveness of the two-month rifampin / pyrazinamide treatment, it could alter the approach to tuberculosis prevention for both HIV-positive and HIV-negative individuals.
NCT00000638 ↗ Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection Completed Lederle Laboratories N/A 1969-12-31 To evaluate and compare the safety and effectiveness of a one-year course of isoniazid (INH) versus a two-month course of rifampin plus pyrazinamide for the prevention of reactivation tuberculosis in individuals infected with both HIV and latent (inactive) Mycobacterium tuberculosis. Current guidelines from the American Thoracic Society and the Centers for Disease Control recommend 6 to 12 months of INH for PPD (purified protein derivative)-positive individuals. Although the effectiveness of this treatment is not known for HIV-infected individuals, several studies using INH to prevent tuberculosis in presumably normal hosts have shown 60 to 80 percent effectiveness. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to tuberculosis organisms being resistant to INH. A two-month preventive treatment plan should help in increasing compliance. In addition, the use of two drugs (rifampin / pyrazinamide) may help overcome problems with drug resistance. If this study shows equal or greater effectiveness of the two-month rifampin / pyrazinamide treatment, it could alter the approach to tuberculosis prevention for both HIV-positive and HIV-negative individuals.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Rifampin

Condition Name

Condition Name for Rifampin
Intervention Trials
Tuberculosis 57
Healthy 33
HIV Infections 24
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Condition MeSH

Condition MeSH for Rifampin
Intervention Trials
Tuberculosis 88
HIV Infections 32
Infections 24
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Clinical Trial Locations for Rifampin

Trials by Country

Trials by Country for Rifampin
Location Trials
United States 414
China 60
Canada 37
South Africa 33
Brazil 25
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Trials by US State

Trials by US State for Rifampin
Location Trials
Texas 48
California 36
Florida 25
New York 25
Maryland 20
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Clinical Trial Progress for Rifampin

Clinical Trial Phase

Clinical Trial Phase for Rifampin
Clinical Trial Phase Trials
Phase 4 32
Phase 3 33
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Rifampin
Clinical Trial Phase Trials
Completed 208
Recruiting 25
Unknown status 16
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Clinical Trial Sponsors for Rifampin

Sponsor Name

Sponsor Name for Rifampin
Sponsor Trials
National Institute of Allergy and Infectious Diseases (NIAID) 21
Pfizer 16
Centers for Disease Control and Prevention 11
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Sponsor Type

Sponsor Type for Rifampin
Sponsor Trials
Other 367
Industry 185
NIH 36
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