Parathyroid Hormone Levels in Relation to the Phosphorus Content of Meals
National Center for Research Resources (NCRR)
Patients on hemodialysis tend to have chronic elevations in the level of phosphorus in the
blood and a secondary increase in the iPTH level. This chronic elevation in iPTH can have
adverse consequences, thus a variety of phosphate binders are given in an attempt to
decrease the absorption of phosphorus present in the normal diet. Some preliminary studies
have indicated that the iPTH level may change based on the amount of phosphorus present in a
meal prior to any significant absorption of phosphorus. If this is true in hemodialysis
patients, then the timing of the administration of phosphate binders in relation to the
ingestion of meals needs to be considered
CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients
The purpose of the study is to evaluate the effects of two phosphate binders, PhosLo and
sevelamer, on heart calcification in dialysis patients. The study will use a non-invasive
technique, electron beam computed tomography (CT) scanning, to measure calcium in the
coronary arteries, the aortic valve, and the mitral valve.
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