Efficacy and Tolerability of Zoledronic Acid With Radiotherapy in Pts With Advanced Osteolytic Bone Lesions
It is the aim of this multicentric clinical study to assess the efficacy and tolerability of
zoledronic acid in combination with radiotherapy in patients with advanced osteolytic bone
lesions in terms of the reduction of pain and analgesic consumption.
This trial will examine the safety, efficacy and feasibility of a single dose of intravenous
zoledronic acid in the maintenance of skeletal integrity for frail, institutionalized women,
who are most at risk for the deleterious outcomes of osteoporosis. The investigators will
test the hypothesis that in institutionalized elderly women a single dose of intravenous
zoledronic acid therapy will: (1) be efficacious as demonstrated by stability or improvement
in bone mass measurements and reductions in bone turnover; (2) be safe and feasible; and (3)
provide estimates for vertebral and nonvertebral fracture reduction in this cohort for use
in planning a future study.
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