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Last Updated: March 28, 2024

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CLINICAL TRIALS PROFILE FOR RINVOQ


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All Clinical Trials for RINVOQ

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02049138 ↗ An Open-label Extension Study Evaluating the Safety and Efficacy of Upadacitinib (ABT-494) in Rheumatoid Arthritis Subjects Completed AbbVie Phase 2 2014-01-24 This is a Phase 2, multicenter, open-label extension study in RA subjects. The sub-study is to assess the impact of upadacitinib treatment (15 mg QD and 30 mg QD) with background MTX on immunological responses to Prevnar 13® in RA patients.
NCT02675426 ↗ A Study Comparing Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on a Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response to csDMARDs Alone Active, not recruiting AbbVie Phase 3 2015-12-17 The primary objectives of this study are to compare the efficacy, safety, and tolerability of upadacitinib 30 mg once daily (QD) and 15 mg QD versus placebo for the treatment of signs and symptoms of adults with moderately to severely active rheumatoid arthritis who were on a stable dose of csDMARDs and had an inadequate response to csDMARDs.
NCT02706847 ↗ A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) With an Inadequate Response or Intolerance to Biologic DMARDs Active, not recruiting AbbVie Phase 3 2016-03-15 The study objective of Period 1 (Day 1 to Week 24) is to compare the safety and efficacy of 30 mg once daily (QD) and 15 mg QD upadacitinib versus placebo for the treatment of signs and symptoms of participants with moderately to severely active RA who were on a stable dose of csDMARDs and had an inadequate response to or intolerance to at least 1 bDMARD. The study objective of Period 2 (Week 24 to Week 260) is to evaluate the long-term safety, tolerability, and efficacy of upadacitinib 15 mg QD and 30 mg QD in participants with RA who completed Period 1.
NCT02706873 ↗ A Study to Compare Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have Not Previously Taken Methotrexate Active, not recruiting AbbVie Phase 3 2016-02-23 The objectives of Period 1 were the following: - To compare the safety and efficacy of upadacitinib 7.5 mg once daily (QD) monotherapy (for participants in Japan only), 15 mg QD monotherapy, and 30 mg QD monotherapy versus weekly methotrexate monotherapy for the treatment of signs and symptoms of RA in methotrexate-naïve adults with moderately to severely active RA; - To compare the efficacy of upadacitinib 15 mg QD monotherapy and upadacitinib 30 mg QD monotherapy versus weekly methotrexate monotherapy for prevention of structural progression in methotrexate-naïve adults with moderately to severely active RA. The objective of Period 2 is to evaluate the long-term safety, tolerability, and efficacy of upadacitinib 7.5 mg QD (for participants in Japan only), 15 mg QD, and 30 mg QD in adults with RA who have completed Period 1.
NCT02706951 ↗ A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY) Active, not recruiting AbbVie Phase 3 2016-03-23 The study objective of Period 1 of this study is to compare the safety and efficacy (signs and symptoms) of upadacitinib 30 mg once daily (QD) alone and upadacitinib 15 mg QD alone versus continuing MTX alone adults with moderately to severely active rheumatoid arthritis (RA) with an inadequate response to MTX. The study objective of Period 2 is to evaluate the long term safety, tolerability, and efficacy of upadacitinib 30 mg QD and 15 mg QD in adults with RA who had completed Period 1.
NCT02782663 ↗ A Study to Evaluate the Long-Term Efficacy, Safety, and Tolerability of Repeated Administration of Upadacitinib (ABT-494) in Participants With Crohn's Disease Active, not recruiting AbbVie Phase 2 2016-05-18 This is a open-label extension (OLE) study designed to evaluate the long-term efficacy, safety, and tolerability of Upadacitinib (ABT-494).
NCT02819635 ↗ A Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis (UC) Active, not recruiting AbbVie Phase 3 2016-09-26 This study comprises three sub-studies. The objective of sub-study 1 is to characterize the dose-response, efficacy, and safety of upadacitinib compared to placebo in inducing clinical remission in order to identify the induction dose of upadacitinib for further evaluation in sub-study 2. The objective of sub-study 2 is to evaluate the efficacy and safety of upadacitinib compared to placebo in inducing clinical remission in participants. The objective of sub-study 3 is to evaluate the efficacy and safety of upadacitinib compared to placebo in achieving clinical remission in participants who had a response following induction with upadacitinib.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for RINVOQ

Condition Name

Condition Name for RINVOQ
Intervention Trials
Rheumatoid Arthritis 8
Atopic Dermatitis 8
Crohn's Disease 3
Ulcerative Colitis (UC) 3
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Condition MeSH

Condition MeSH for RINVOQ
Intervention Trials
Arthritis 10
Dermatitis, Atopic 9
Dermatitis 9
Eczema 9
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Clinical Trial Locations for RINVOQ

Trials by Country

Trials by Country for RINVOQ
Location Trials
United States 699
Japan 318
China 128
Canada 112
Poland 107
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Trials by US State

Trials by US State for RINVOQ
Location Trials
Ohio 29
Florida 28
California 28
Texas 28
Michigan 25
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Clinical Trial Progress for RINVOQ

Clinical Trial Phase

Clinical Trial Phase for RINVOQ
Clinical Trial Phase Trials
Phase 4 4
Phase 3 26
Phase 2 6
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Clinical Trial Status

Clinical Trial Status for RINVOQ
Clinical Trial Phase Trials
Active, not recruiting 15
Not yet recruiting 10
Recruiting 4
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Clinical Trial Sponsors for RINVOQ

Sponsor Name

Sponsor Name for RINVOQ
Sponsor Trials
AbbVie 35
University of Nebraska 1
University of Pennsylvania 1
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Sponsor Type

Sponsor Type for RINVOQ
Sponsor Trials
Industry 39
Other 8
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