Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine
National Institute of Allergy and Infectious Diseases (NIAID)
Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and
eliminated through the kidneys in HIV infected patients. Part II studies the effect of
probenecid and quinine on the same aspects.
Because AZT leaves the bloodstream quickly, patients must take the drug frequently to keep
adequate amounts in their bodies. Probenecid and quinine may slow down the rate at which AZT
leaves the body. Therefore, taking these drugs along with AZT may reduce the amount of AZT
needed for treatment.
A Dose Proportionality Study of Quinine Sulfate Capsules Under Fasting Conditions
Mutual Pharmaceutical Company, Inc.
The purpose of this study is to evaluate and compare the dose proportionality of 324 mg
Quinine Sulfate capsules following a single oral dose (1 x 324 mg capsules versus 2 x 324 mg
capsules) in healthy adult volunteers when administered under fasting conditions.
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