Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia
The Hospital for Sick Children
This is a randomized, double-blind, multi-centered study to compare 6 months of medical
treatment with digoxin or propranolol in infants with SVT Background: SVT is the most common
sustained arrhythmia of infancy. Neither digoxin nor propranolol has been evaluated for
pediatric use in a controlled trial in the context of SVT, yet both medications are used
Specific aims of the study:
To determine whether propranolol and digoxin differ in the:
1. Incidence of recurrent SVT in infants after 6 months of treatment with propranolol or
2. Time to first recurrence of SVT in infants treated with propranolol or digoxin.
3. Incidence of adverse outcomes in infants treated with propranolol or digoxin.
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