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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR PROAMATINE


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All Clinical Trials for Proamatine

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00046163 ↗ A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension Terminated Shire Phase 4 2002-09-05 We are seeking male and female patients to voluntarily take part in a clinical research study. Patients must be aged 18 or older and diagnosed with symptomatic orthostatic hypotension (low blood pressure while in the upright position) due to Parkinson's disease, multiple system atrophy, pure autonomic failure or autonomic neuropathies (i.e. neurogenic orthostatic hypotension). Symptoms of low blood pressure include dizziness, lightheadedness, changes in vision and generalized weakness upon standing. The main effect of the drug being studied is to increase blood pressure in the upright position so symptoms will decrease. The purpose of this clinical study is to further assess the clinical effect of high dose midodrine hydrochloride (ProAmatine®), an approved treatment for orthostatic hypotension. During the course of the study, participants will receive either ProAmatine® or a placebo. Assessments will be made using questionnaires that measure symptom and activity levels. Blood pressure in the lying down, sitting and standing positions will be measured. Patients will also complete standing time assessments. They will be asked to remain standing without moving until they feel sufficiently lightheaded, or dizzy, or feel faint so that they would feel more comfortable sitting down.
NCT00046475 ↗ A Study for Patients With Neurogenic Orthostatic Hypotension Completed Shire Phase 4 1997-12-01 We are seeking male and female patients to voluntarily take part in a clinical research study. Patients must be aged 18 or older and diagnosed with symptomatic orthostatic hypotension (low blood pressure while in the upright position) due to Parkinson's disease, multiple system atrophy, pure autonomic failure or autonomic neuropathies (i.e. neurogenic orthostatic hypotension). Symptoms of low blood pressure include dizziness, lightheadedness, changes in vision and generalized weakness upon standing. The main effect of the drug being studied is to increase blood pressure in the upright position so symptoms will decrease. The purpose of this clinical study is to further assess the clinical benefit of midodrine hydrochloride (ProAmatine®), an approved treatment for orthostatic hypotension. During the course of the study, participants will receive either ProAmatine® or a placebo. Assessments will be made using questionnaires that measure symptom and activity levels. Blood pressure in the lying down and standing positions will be measured at each visit.
NCT00223691 ↗ Treatment of Orthostatic Hypotension in Autonomic Failure Completed Vanderbilt University Phase 1 2002-03-01 The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function. There are several diseases characterized by abnormal function of the autonomic nervous system. Medications can also alter autonomic function. Impairment of the autonomic nervous system by diseases or drugs may lead to several symptoms, including blood pressure problems (e.g., high blood pressure lying down and low blood pressure on standing), sweating abnormalities, constipation or diarrhea and sexual dysfunction. Because treatment options for these patients are limited. We propose to study patients autonomic failure and low blood pressure upon standing and determine the cause of their disease by history and examination and their response to autonomic testing which have already been standardized in our laboratory. Based on their possible cause, we will tests different medications that may alleviate their symptoms.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Proamatine

Condition Name

Condition Name for Proamatine
Intervention Trials
Healthy 3
Hypotension, Orthostatic 3
Orthostatic Hypotension 3
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Condition MeSH

Condition MeSH for Proamatine
Intervention Trials
Hypotension 7
Hypotension, Orthostatic 6
Pure Autonomic Failure 2
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Clinical Trial Locations for Proamatine

Trials by Country

Trials by Country for Proamatine
Location Trials
United States 35
Egypt 1
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Trials by US State

Trials by US State for Proamatine
Location Trials
New York 5
West Virginia 4
Texas 3
Tennessee 3
Ohio 2
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Clinical Trial Progress for Proamatine

Clinical Trial Phase

Clinical Trial Phase for Proamatine
Clinical Trial Phase Trials
Phase 4 6
Phase 1 5
N/A 2
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Clinical Trial Status

Clinical Trial Status for Proamatine
Clinical Trial Phase Trials
Completed 7
Recruiting 2
Terminated 2
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Clinical Trial Sponsors for Proamatine

Sponsor Name

Sponsor Name for Proamatine
Sponsor Trials
Shire 3
Mylan Pharmaceuticals 3
Vanderbilt University 2
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Sponsor Type

Sponsor Type for Proamatine
Sponsor Trials
Other 8
Industry 6
U.S. Fed 2
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