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CLINICAL TRIALS PROFILE FOR PREMARIN

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Clinical Trials for Premarin

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00000175	The Effects of Sex Hormones on Cognition and Mood in Older Adults	Terminated	National Institute on Aging (NIA)	N/A	This study is investigating the effects of hormone replacement therapy on memory, mental abilities and mood in older adults aged 65-90. During the nine month long study, men will take testosterone for three months and women will take estrogen for three months. At four points during the study (once every three months), participants will complete a test battery and have blood drawn.
NCT00000555	Women's Angiographic Vitamin and Estrogen Trial (WAVE)	Completed	National Heart, Lung, and Blood Institute (NHLBI)	Phase 3	To assess whether hormonal replacement therapy and/or antioxidant treatment would stabilize or inhibit progression, and induce regression of coronary plaques. The mechanisms by which these treatments modified atherosclerosis in women were also explored.
NCT00002976	Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer	Terminated	Eastern Cooperative Oncology Group	Phase 3	RATIONALE: Estrogen replacement therapy may improve quality-of-life in postmenopausal women with endometrial cancer. It is not yet known whether estrogen replacement therapy will affect cancer recurrence. PURPOSE: Randomized double-blinded phase III trial to determine the effectiveness of estrogen replacement therapy in treating women who have stage I or stage II endometrial cancer.
NCT00002976	Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer	Terminated	National Cancer Institute (NCI)	Phase 3	RATIONALE: Estrogen replacement therapy may improve quality-of-life in postmenopausal women with endometrial cancer. It is not yet known whether estrogen replacement therapy will affect cancer recurrence. PURPOSE: Randomized double-blinded phase III trial to determine the effectiveness of estrogen replacement therapy in treating women who have stage I or stage II endometrial cancer.

Clinical Trial Conditions for Premarin

Condition Name

Condition Name for Premarin
Intervention	Trials
Postmenopause	10
Menopause	7
Heart Diseases	2
Atrophic Vaginitis	2

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Condition MeSH

Condition MeSH for Premarin
Intervention	Trials
Vaginitis	3
Arteriosclerosis	3
Atrophy	2
Heart Diseases	2

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Clinical Trial Locations for Premarin

Trials by Country

Trials by Country for Premarin
Location	Trials
United States	126
Canada	6
Brazil	1
Japan	1
Mexico	1

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Trials by US State

Trials by US State for Premarin
Location	Trials
Massachusetts	8
Florida	8
California	6
Maryland	6
Texas	5

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Clinical Trial Progress for Premarin

Clinical Trial Phase

Clinical Trial Phase for Premarin
Clinical Trial Phase	Trials
Phase 4	7
Phase 3	7
Phase 2/Phase 3	2

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Clinical Trial Status

Clinical Trial Status for Premarin
Clinical Trial Phase	Trials
Completed	33
Terminated	4
Unknown status	4

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Clinical Trial Sponsors for Premarin

Sponsor Name

Sponsor Name for Premarin
Sponsor	Trials
Wyeth is now a wholly owned subsidiary of Pfizer	13
University of Washington	4
Brigham and Women's Hospital	4

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Sponsor Type

Sponsor Type for Premarin
Sponsor	Trials
Other	56
Industry	21
NIH	8

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