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Last Updated: October 20, 2019

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CLINICAL TRIALS PROFILE FOR POTASSIUM CITRATE

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Clinical Trials for Potassium Citrate

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00004284 Phase III Randomized, Double-Blind Study of Potassium Phosphate Vs Potassium Citrate for Absorptive Hypercalciuria Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 3 1995-04-01 OBJECTIVES: I. Evaluate the ability of a slow-releasing formulation of neutral potassium phosphate to correct hypercalciuria and prevent recurrent stone formation in patients with absorptive hypercalciuria. II. Evaluate the safety of this treatment. III. Compare the efficacy of potassium phosphate to that of potassium citrate.
NCT00004284 Phase III Randomized, Double-Blind Study of Potassium Phosphate Vs Potassium Citrate for Absorptive Hypercalciuria Completed University of Texas Phase 3 1995-04-01 OBJECTIVES: I. Evaluate the ability of a slow-releasing formulation of neutral potassium phosphate to correct hypercalciuria and prevent recurrent stone formation in patients with absorptive hypercalciuria. II. Evaluate the safety of this treatment. III. Compare the efficacy of potassium phosphate to that of potassium citrate.
NCT00004284 Phase III Randomized, Double-Blind Study of Potassium Phosphate Vs Potassium Citrate for Absorptive Hypercalciuria Completed National Center for Research Resources (NCRR) Phase 3 1995-04-01 OBJECTIVES: I. Evaluate the ability of a slow-releasing formulation of neutral potassium phosphate to correct hypercalciuria and prevent recurrent stone formation in patients with absorptive hypercalciuria. II. Evaluate the safety of this treatment. III. Compare the efficacy of potassium phosphate to that of potassium citrate.
NCT00120731 Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones Completed Children's Mercy Hospital Kansas City N/A 2005-07-01 High amounts of calcium in the urine (hypercalciuria) can cause development of kidney stones in children. Treatment for these children includes plenty of fluids, a low-salt diet and medications such as potassium citrate. A major advantage of potassium citrate, as compared to hydrochlorothiazide, is its lack of side effects. One problem the researchers and others have observed is that some children continue to form kidney stones despite correction of hypercalciuria with potassium citrate. One possible explanation is that in some individuals potassium citrate therapy results in an excessive elevation of urine pH, a situation that may predispose to calcium phosphate stone formation. In this study, the researchers will study the effects of potassium citrate on urine chemistries and acid-base balance in three groups of children aged 5-17 years: - children who are hypercalciuric stone formers; - healthy children without a history of hypercalciuria or kidney stones. Particular attention will be paid to try to identify those who develop a very high urine pH (>8) and the factors leading to this metabolic reaction. The researchers will try to learn whether it is the child’s characteristics, the disease manifestations, the dose of the drug, or a combination of the above which may be the cause of the development of very alkaline urine. Based on the results, the researchers hope to be able to better “tailor” the individual treatment for each child with kidney stones.
NCT00244777 Introduction of Hypo-osmolar ORS for Routine Use Completed United States Agency for International Development (USAID) Phase 4 2002-12-01 The World Health Organization has very recently recommended the routine use of a hypo-osmolar ORS in the management of diarrhoeal diseases. This recommendation is based on the better efficacy of the hypo-osmolar ORS over the standard WHO ORS demonstrated in controlled clinical trials. The recommendation, however, also expressed the need for "careful monitoring to better assess risk, if any, of symptomatic hyponatraemia". There thus is a need for phase IV trials before the new solution is introduced into routine clinical practice to assess the risk in relatively large number of patient populations. The proposed study will be carried out at two different settings- at the urban settings of the Dhaka Hospital (60000 patients) and at the rural settings of the Matlab Hospital (15000 patients) of ICDDR,B. The hypo-osmolar rice or glucose-based ORS will be introduced as standard management of patients with diarrhoea . The hypo-osmolar ORS will contain 75 mmol /L of sodium instead of 90 mmol/L. Surveillance will be carried out to detect adverse events focusing on the occurrence of seizures or undue lethargy during hospitalization. Each episode of seizure or undue lethargy would be evaluated to determine if they are associated with abnormal levels of serum sodium or glucose, or fever. It has been estimated that about 3% (1,800) of patients initially admitted to the Short Stay Ward of the Dhaka Hospital, and 340 patients at the Matlab Hospital might require admission to the longer stay inpatient wards due to seizure or altered consciousness. Such patients would be thoroughly assessed including determination of their serum sodium and glucose, two common causes of seizures/altered consciousness, to determine if and to what extent they could be attributed to hyponatraemia.The results from this study would be used in planning and implementing the routine use of the new formulation of ORS at all Government, NGO and private health care facilities that treat diarrhoeal patients, in Bangladesh and in other countries.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Potassium Citrate

Condition Name

Condition Name for Potassium Citrate
Intervention Trials
Hypertension 5
Urolithiasis 4
Nephropathy 3
Cardiovascular Diseases 3
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Condition MeSH

Condition MeSH for Potassium Citrate
Intervention Trials
Kidney Calculi 7
Nephrolithiasis 7
Urolithiasis 5
Calculi 5
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Clinical Trial Locations for Potassium Citrate

Trials by Country

Trials by Country for Potassium Citrate
Location Trials
United States 13
China 8
Canada 4
Denmark 3
Egypt 2
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Trials by US State

Trials by US State for Potassium Citrate
Location Trials
Texas 6
Wisconsin 1
Pennsylvania 1
Illinois 1
Minnesota 1
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Clinical Trial Progress for Potassium Citrate

Clinical Trial Phase

Clinical Trial Phase for Potassium Citrate
Clinical Trial Phase Trials
Phase 4 12
Phase 3 6
Phase 2 9
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Clinical Trial Status

Clinical Trial Status for Potassium Citrate
Clinical Trial Phase Trials
Completed 15
Recruiting 9
Not yet recruiting 4
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Clinical Trial Sponsors for Potassium Citrate

Sponsor Name

Sponsor Name for Potassium Citrate
Sponsor Trials
University of Texas Southwestern Medical Center 5
Erling Bjerregaard Pedersen 2
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2
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Sponsor Type

Sponsor Type for Potassium Citrate
Sponsor Trials
Other 43
Industry 10
NIH 4
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