CLINICAL TRIALS PROFILE FOR PONESIMOD
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All Clinical Trials for Ponesimod
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT01093326 ↗ | Clinical Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Ponesimod in Patients With Relapsing-remitting Multiple Sclerosis | Active, not recruiting | Actelion | Phase 2 | 2010-05-01 | This study is an extension to the study AC-058B201 and will investigate the long-term safety, tolerability and efficacy of ponesimod in patients with relapsing-remitting multiple sclerosis. |
| NCT02068235 ↗ | Study to Investigate the Absolute Bioavailability of a Single Oral Dose of Ponesimod in Healthy Male Subjects | Completed | Actelion | Phase 1 | 2014-08-01 | This study consists of a single-dose pilot phase and a randomized, two-way crossover, single-dose main phase.The aim of this study is to evaluate the absolute bioavailability of the oral formulation (tablet) of ponesimod compared to an intravenous (i.v.) ponesimod formulation. Three subjects will be included in the pilot phase and 12 subjects in the main crossover phase. |
| NCT02136888 ↗ | Study of the Electrocardiographic Effects of Ponesimod in Healthy Male and Female Subjects | Completed | Actelion | Phase 1 | 2011-08-01 | The aim of this study is to demonstrate that therapeutic and supratherapeutic plasma exposures to ponesimod do not have an effect on cardiac repolarization exceeding the threshold of regulatory concern as measured by the QTc (interval from beginning of the Q wave until end of the T wave corrected for heart rate) interval duration after administration of multiple oral doses of 40 mg and 100 mg to healthy male and female subjects. |
| NCT02425644 ↗ | Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis | Completed | Actelion | Phase 3 | 2015-06-04 | International clinical trial to compare ponesimod and teriflunomide in relapsing multiple sclerosis |
| NCT02461134 ↗ | Clinical Study to Investigate the Biological Activity, Safety, Tolerability, and Pharmacokinetics of Ponesimod in Subjects With Symptomatic Chronic GVHD | Terminated | Actelion | Phase 2 | 2016-09-29 | Chronic graft versus host diseasre (GVHD) is a serious reaction that might occur in a person (the host) who has received cells or organs (graft) from another person because the graft attacks the host's cells. Currently there are no approved therapies for chronic GVHD in the USA, and patients with chroninc GVHD are treated with immunosuppressant drugs. T-lymphocytes (a type of white blood cells) are likely to play a role in the development of chronic GVHD. Due to the capacity of ponesimod to block the traffic of T-lymphocytes, ponesimod may be a new therapeutic approach to treat chroninc GVHD. The main objective of this study is to assess the effectiveness and safety of several doses of ponesimod in subjects with chronic GVHD who did not respond to standard available treatments. |
| NCT02907177 ↗ | Clinical Study to Compare the Efficacy and Safety of Ponesimod to Placebo in Subjects With Active Relapsing Multiple Sclerosis Who Are Treated With Dimethyl Fumarate (Tecfidera®) | Terminated | Actelion | Phase 3 | 2017-03-30 | This clinical study compares the efficacy, safety, and tolerability of therapy with ponesimod vs placebo in subjects with active RMS who are treated with DMF (Tecfidera®). |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
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