Study to Investigate the Absolute Bioavailability of a Single Oral Dose of Ponesimod in Healthy Male Subjects
This study consists of a single-dose pilot phase and a randomized, two-way crossover,
single-dose main phase.The aim of this study is to evaluate the absolute bioavailability of
the oral formulation (tablet) of ponesimod compared to an intravenous (i.v.) ponesimod
formulation. Three subjects will be included in the pilot phase and 12 subjects in the main
Study of the Electrocardiographic Effects of Ponesimod in Healthy Male and Female Subjects
The aim of this study is to demonstrate that therapeutic and supratherapeutic plasma
exposures to ponesimod do not have an effect on cardiac repolarization exceeding the
threshold of regulatory concern as measured by the QTc (interval from beginning of the Q wave
until end of the T wave corrected for heart rate) interval duration after administration of
multiple oral doses of 40 mg and 100 mg to healthy male and female subjects.
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