Cardiovascular System in Obesity: Effect of Treatment
National Heart, Lung, and Blood Institute (NHLBI)
To determine the long-term efficacy of the combination therapy of phentermine and
fenfluramine in conjunction with diet, exercise, and behavior modification in the treatment
of simple, moderate obesity.
A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects
This study will examine the safety, tolerability, and body weight effect of subcutaneous
pramlintide alone and in various combinations with the oral antiobesity agents sibutramine
or phentermine in overweight and obese subjects.
Pharmacokinetic Comparison of Multiple Formulations of Topiramate and Phentermine in Obese Adults
The primary objective of this study is to describe the single- and multiple-dose
pharmacokinetic profiles of two novel formulations of topiramate and commercially available
immediate release topiramate, all dosed with immediate release phentermine.
A Study Comparing Multiple Doses of VI-0521 With Placebo and Their Single-agent Constituents for Treatment of Obesity in Adults
The objective of this study is to evaluate the safety and efficacy of various doses of
VI-0521 compared to both placebo, and the single-agent components that comprise each
combination dose. This study will provide confirmatory data to demonstrate that doses of
VI-0521 have efficacy that is greater than placebo and each of the single-agent components
that comprise the combination dose.
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