Cardiovascular System in Obesity: Effect of Treatment
Completed
National Heart, Lung, and Blood Institute (NHLBI)
Phase 2
1983-05-01
To determine the long-term efficacy of the combination therapy of phentermine and
fenfluramine in conjunction with diet, exercise, and behavior modification in the treatment
of simple, moderate obesity.
A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects
Completed
AstraZeneca
Phase 2
2006-11-01
This study will examine the safety, tolerability, and body weight effect of subcutaneous
pramlintide alone and in various combinations with the oral antiobesity agents sibutramine or
phentermine in overweight and obese subjects.
Pharmacokinetic Comparison of Multiple Formulations of Topiramate and Phentermine in Obese Adults
Completed
VIVUS, Inc.
Phase 1
2007-07-01
The primary objective of this study is to describe the single- and multiple-dose
pharmacokinetic profiles of two novel formulations of topiramate and commercially available
immediate release topiramate, all dosed with immediate release phentermine.
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