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Last Updated: December 12, 2024

CLINICAL TRIALS PROFILE FOR PERIOSTAT


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All Clinical Trials for Periostat

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00041977 ↗ Determine the Effect of Administering Periostat(R) Twice Daily on Patients With Acne Rosacea Completed CollaGenex Pharmaceuticals Phase 3 2002-06-01 The purpose of this study is to determine whether Periostat(R), Doxycycline Hyclate 20 mg Tablets, taken twice daily is effective in reducing the red and white heads and overall redness associated with rosacea.
NCT00246740 ↗ Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting Completed University of Alberta Phase 2 2005-10-01 The purpose of this study is to determine whether doxycycline (Periostat) at a sub-antimicrobial dose will decrease reperfusion injury after coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB).
NCT00358462 ↗ Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA) Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 2007-01-01 The purpose of this study is to find out which of 2 different antibiotics, doxycycline or azithromycin, works best against germs that may cause nongonococcal urethritis. Study participants will include approximately 1200 men, 16 years of age or older, attending a sexually transmitted diseases clinic in Seattle, Washington with clinical signs of urethral inflammation (>=5PMNs/HPF on a Gram-stained slide prepared from urethral exudates and/or a visible urethral discharge upon examination). Urine specimens will be collected and tested for Mycoplasma genitalium and Ureaplasmas. Each participant will receive a blinded packet of study medication. Participants will answer an enrollment questionnaire and will also receive a log to complete between visits to record information about treatment adherence, side effects, symptoms, and sexual activity. All subjects will be asked to return for evaluation 3 weeks after the initial clinic visit. Subjects who test positive for M. genitalium and/or Ureaplasmas at the initial clinic visit will also be asked to return for a third study visit, 6 weeks following the initial clinic visit. During follow-up visits, participants will answer a follow-up questionnaire and will be re-evaluated for signs of urethritis. Those who were initially positive for M. genitalium and/or Ureaplasmas will be re-tested for these organisms. Study participants with signs and/or symptoms of urethritis or who test positive for M. genitalium or Ureaplasmas at the follow-up study visit will receive another blinded treatment packet containing the alternate medication. Those who require additional treatment at the 6-week visit will be asked to return for a fourth follow-up study visit at 9-10 weeks. Study participants who did not test positive for M. genitalium or Ureaplasmas at the initial clinic visit, but who continue to demonstrate signs and/or symptoms of infection at their single follow-up study visit will treated according to clinic standard of care (after the study clinician unblinds their randomly-assigned treatment regimen).
NCT00358462 ↗ Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA) Completed University of Washington Phase 3 2007-01-01 The purpose of this study is to find out which of 2 different antibiotics, doxycycline or azithromycin, works best against germs that may cause nongonococcal urethritis. Study participants will include approximately 1200 men, 16 years of age or older, attending a sexually transmitted diseases clinic in Seattle, Washington with clinical signs of urethral inflammation (>=5PMNs/HPF on a Gram-stained slide prepared from urethral exudates and/or a visible urethral discharge upon examination). Urine specimens will be collected and tested for Mycoplasma genitalium and Ureaplasmas. Each participant will receive a blinded packet of study medication. Participants will answer an enrollment questionnaire and will also receive a log to complete between visits to record information about treatment adherence, side effects, symptoms, and sexual activity. All subjects will be asked to return for evaluation 3 weeks after the initial clinic visit. Subjects who test positive for M. genitalium and/or Ureaplasmas at the initial clinic visit will also be asked to return for a third study visit, 6 weeks following the initial clinic visit. During follow-up visits, participants will answer a follow-up questionnaire and will be re-evaluated for signs of urethritis. Those who were initially positive for M. genitalium and/or Ureaplasmas will be re-tested for these organisms. Study participants with signs and/or symptoms of urethritis or who test positive for M. genitalium or Ureaplasmas at the follow-up study visit will receive another blinded treatment packet containing the alternate medication. Those who require additional treatment at the 6-week visit will be asked to return for a fourth follow-up study visit at 9-10 weeks. Study participants who did not test positive for M. genitalium or Ureaplasmas at the initial clinic visit, but who continue to demonstrate signs and/or symptoms of infection at their single follow-up study visit will treated according to clinic standard of care (after the study clinician unblinds their randomly-assigned treatment regimen).
NCT02388477 ↗ Trial of the Use of Doxycycline After Rotator Cuff Repair Withdrawn Milton S. Hershey Medical Center N/A 1969-12-31 The purpose of this study is to examine healing after rotator cuff repair in subjects either treated with Doxycycline or placebo post-operatively.
NCT02623959 ↗ Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis Terminated M.D. Anderson Cancer Center Phase 4 2016-04-27 The goal of this clinical research study is to compare indwelling pleural catheters (IPC) in combination with saline (the current standard of care) versus IPC in combination with doxycycline as treatment for pleural effusions.
NCT03435952 ↗ Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT Recruiting BioMed Valley Discoveries, Inc Phase 1 2018-07-10 Some tumors are difficult to treat with chemotherapy or radiation. One of the reasons is that areas of the tumor do not have many blood vessels, which makes it difficult for drugs to reach those areas. One way that researchers have recently tried to overcome this problem is by injecting special kinds of bacteria into the tumors. These bacteria have been genetically changed to remove the chemicals that are poisonous to humans, but are still able to cause tumor cells to break down and die. The idea is that these bacteria may be able to assist chemotherapy drugs in fighting cancer. The goal of this clinical research study is to find the highest tolerable dose of one of these bacterial therapies (Clostridium novyi-NT spores) that can be given in combination with pembrolizumab to patients with advanced solid tumors. The safety of this drug will also be studied, as well as whether it can help to control the disease. This is an investigational study. Clostridium novyi-NT is not FDA approved or commercially available. It is currently being used for research purposes only. Pembrolizumab is FDA approved for the treatment of melanoma and different types of head and neck and non-small cell lung cancers. It is investigational to use these drugs in combination with each other in various types of advanced cancers. The study doctor can describe how the study drugs are designed to work. Up to 18 participants will be enrolled in this study. All will take part at MD Anderson.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Periostat

Condition Name

Condition Name for Periostat
Intervention Trials
Malignant Neoplasms of Respiratory and Intrathoracic Organs 2
Rotator Cuff Injury 1
Malignant Neoplasms of Independent (Primary) Multiple Sites 1
Urethritis 1
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Condition MeSH

Condition MeSH for Periostat
Intervention Trials
Pleural Effusion, Malignant 2
Neoplasms 2
Pleural Effusion 2
Genital Neoplasms, Female 1
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Clinical Trial Locations for Periostat

Trials by Country

Trials by Country for Periostat
Location Trials
United States 9
Canada 1
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Trials by US State

Trials by US State for Periostat
Location Trials
Texas 3
Pennsylvania 2
Washington 1
Virginia 1
Kentucky 1
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Clinical Trial Progress for Periostat

Clinical Trial Phase

Clinical Trial Phase for Periostat
Clinical Trial Phase Trials
Phase 4 1
Phase 3 2
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Periostat
Clinical Trial Phase Trials
Completed 3
Recruiting 2
Terminated 1
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Clinical Trial Sponsors for Periostat

Sponsor Name

Sponsor Name for Periostat
Sponsor Trials
M.D. Anderson Cancer Center 3
Merck Sharp & Dohme Corp. 1
National Cancer Institute (NCI) 1
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Sponsor Type

Sponsor Type for Periostat
Sponsor Trials
Other 6
Industry 3
NIH 2
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