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Last Updated: November 12, 2024

CLINICAL TRIALS PROFILE FOR PAROXETINE HYDROCHLORIDE


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All Clinical Trials for Paroxetine Hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000368 ↗ Treatment of Panic Disorder: Long Term Strategies Completed National Institute of Mental Health (NIMH) Phase 3 1999-02-01 Cognitive behavior therapy (CBT) with or without medication has been used in the treatment of panic disorder (PD). The purpose of this study is 1) to determine whether nine months of maintenance cognitive-behavior therapy (CBT) significantly improves the likelihood of sustained improvement; and 2) to determine the acute acceptability and efficacy of medication therapy or continued CBT alone among patients who fail to respond sufficiently to an initial course of CBT alone. It has been found that patients with PD respond as well to CBT or medication alone as they do to a combination of the two. Since the combined treatments are expensive and CBT is associated with less risk of medical toxicity compared to medications, CBT alone will be used first. All patients will first receive CBT alone. If the patient responds to this therapy, the patient will be assigned randomly (like tossing a coin) to 1 of 2 groups. One group will continue to receive CBT (maintenance therapy) for 9 months. The other group of responders will not receive any further therapy. If a patient does not respond to CBT alone, he/she will be assigned randomly to 1 of 2 different groups. One group will receive paroxetine; the other will continue to receive CBT for a longer period. The response to treatment will be evaluated to see which regimen works best to treat PD. The study will last approximately 3 years. An individual may be eligible for this study if he/she has panic disorder with no more than mild agoraphobia (fear of being in public places) and is at least 18 years old.
NCT00000368 ↗ Treatment of Panic Disorder: Long Term Strategies Completed New York State Psychiatric Institute Phase 3 1999-02-01 Cognitive behavior therapy (CBT) with or without medication has been used in the treatment of panic disorder (PD). The purpose of this study is 1) to determine whether nine months of maintenance cognitive-behavior therapy (CBT) significantly improves the likelihood of sustained improvement; and 2) to determine the acute acceptability and efficacy of medication therapy or continued CBT alone among patients who fail to respond sufficiently to an initial course of CBT alone. It has been found that patients with PD respond as well to CBT or medication alone as they do to a combination of the two. Since the combined treatments are expensive and CBT is associated with less risk of medical toxicity compared to medications, CBT alone will be used first. All patients will first receive CBT alone. If the patient responds to this therapy, the patient will be assigned randomly (like tossing a coin) to 1 of 2 groups. One group will continue to receive CBT (maintenance therapy) for 9 months. The other group of responders will not receive any further therapy. If a patient does not respond to CBT alone, he/she will be assigned randomly to 1 of 2 different groups. One group will receive paroxetine; the other will continue to receive CBT for a longer period. The response to treatment will be evaluated to see which regimen works best to treat PD. The study will last approximately 3 years. An individual may be eligible for this study if he/she has panic disorder with no more than mild agoraphobia (fear of being in public places) and is at least 18 years old.
NCT00012558 ↗ Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) Completed National Institute of Mental Health (NIMH) N/A 1998-09-01 A long-term study of current treatments for bipolar disorder, including medications and psychosocial therapies.
NCT00018733 ↗ Biological Aspects of Depression and Antidepressant Drugs Completed US Department of Veterans Affairs N/A 1996-09-01 This study will be measuring changes in depressive symptoms over a 7 week time period. Double-blind placebo controlled trial using the pharmacologic agents Paroxetine or Desipramine.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Paroxetine Hydrochloride

Condition Name

Condition Name for Paroxetine Hydrochloride
Intervention Trials
Depression 26
Major Depressive Disorder 25
Depressive Disorder 20
Healthy 17
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Condition MeSH

Condition MeSH for Paroxetine Hydrochloride
Intervention Trials
Depression 93
Disease 84
Depressive Disorder 81
Depressive Disorder, Major 53
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Clinical Trial Locations for Paroxetine Hydrochloride

Trials by Country

Trials by Country for Paroxetine Hydrochloride
Location Trials
United States 501
Canada 42
Germany 31
China 30
Japan 17
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Trials by US State

Trials by US State for Paroxetine Hydrochloride
Location Trials
New York 34
California 31
Pennsylvania 28
Texas 23
Florida 23
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Clinical Trial Progress for Paroxetine Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Paroxetine Hydrochloride
Clinical Trial Phase Trials
Phase 4 74
Phase 3 55
Phase 2/Phase 3 5
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Clinical Trial Status

Clinical Trial Status for Paroxetine Hydrochloride
Clinical Trial Phase Trials
Completed 188
Terminated 19
Unknown status 19
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Clinical Trial Sponsors for Paroxetine Hydrochloride

Sponsor Name

Sponsor Name for Paroxetine Hydrochloride
Sponsor Trials
GlaxoSmithKline 54
National Institute of Mental Health (NIMH) 17
Sanofi 12
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Sponsor Type

Sponsor Type for Paroxetine Hydrochloride
Sponsor Trials
Other 224
Industry 143
U.S. Fed 36
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