A Study to Evaluate the Effects of Different Methods of Birth Control on the Drug Actions of Zidovudine (an Anti-HIV Drug) in HIV-Positive Women and to Compare Zidovudine Metabolism in Men and Women
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
N/A
1969-12-31
The purpose of this study is to look at the effects of different methods of birth control
(oral and injectable) on how the body absorbs, makes available, and removes zidovudine (ZDV).
This study will also evaluate the differences in men and women in how the body absorbs, makes
available, and removes ZDV.
Past research has shown that the effectiveness of ZDV as an anti-HIV drug might be decreased
in individuals who use certain methods of birth control. ZDV may also have different effects
in men compared to women.
Surgery Plus Medroxyprogesterone in Preventing Endometrial Cancer
Terminated
National Cancer Institute (NCI)
Phase 2
1998-11-01
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the
development or recurrence of cancer. The use of surgery with or without medroxyprogesterone
may be an effective way to prevent the development of endometrial cancer in patients who have
endometrial hyperplasia.
PURPOSE: Phase II trial to compare the effectiveness of surgery alone with that of
medroxyprogesterone followed by surgery in preventing endometrial cancer in patients who have
endometrial hyperplasia.
Surgery Plus Medroxyprogesterone in Preventing Endometrial Cancer
Terminated
Gynecologic Oncology Group
Phase 2
1998-11-01
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the
development or recurrence of cancer. The use of surgery with or without medroxyprogesterone
may be an effective way to prevent the development of endometrial cancer in patients who have
endometrial hyperplasia.
PURPOSE: Phase II trial to compare the effectiveness of surgery alone with that of
medroxyprogesterone followed by surgery in preventing endometrial cancer in patients who have
endometrial hyperplasia.
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