Vasomotor Symptoms (VMS) Progesterone Study: Vasomotor Symptoms and Endothelial Function - Trial of Oral Micronized Progesterone
Unknown status
University of British Columbia
Phase 2
2005-09-01
The primary purpose of this study is to determine the effects of a full dose (300 mg at hs)
of oral micronized progesterone (OMP) on vasomotor symptoms [VMS] (hot flushes/night sweats),
on forearm blood flow and on lipid levels and blood pressure in menopausal women without
cardiovascular disease and with moderate to severe VMS.
The hypotheses are that progesterone will improve hot flushes, increase endothelium-dependent
forearm blood flow and will decrease blood pressure without change in lipid levels.
The study will examine the effects of estrogen and progesterone on the development of
atherosclerosis in menopausal women when hormone treatment is initiated within 3 years of the
menopausal transition.
Albert Einstein College of Medicine of Yeshiva University
Phase 4
2005-09-01
The study will examine the effects of estrogen and progesterone on the development of
atherosclerosis in menopausal women when hormone treatment is initiated within 3 years of the
menopausal transition.
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