Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy
Completed
The Hospital for Sick Children
Phase 2
2006-05-01
To study the effect of combined diazoxide-metformin therapy on body weight in youth with
hypothalamic obesity following treatment for craniopharyngioma. A secondary objective is to
evaluate changes in insulin resistance (IR), beta-cell function, features of the metabolic
syndrome, muscle metabolism and intramyocellular lipid.
Hypothesis: Treatment with diazoxide and metformin will result in weight loss or slowed
weight gain and improved metabolic profile, compared to pretreatment levels.
To replace Sandostatine® in three daily subcutaneous injections by a single intramuscular
injection of Sandostatine® LP per month in patients with a diffuse form of hyperinsulinism.
To replace Sandostatine® in three daily subcutaneous injections by a single intramuscular
injection of Sandostatine® LP per month in patients with a diffuse form of hyperinsulinism.
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