Last Updated: September 25, 2026

CLINICAL TRIALS PROFILE FOR PROCHLORPERAZINE


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All Clinical Trials for PROCHLORPERAZINE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00020657 ↗ Comparison of Antiemetic Drugs in Preventing Delayed Nausea After Chemotherapy in Patients With Cancer Completed National Cancer Institute (NCI) Phase 3 2001-07-01 RATIONALE: Antiemetic drugs may help to reduce or prevent nausea and vomiting in patients being treated with chemotherapy. PURPOSE: This randomized phase III trial is comparing how well different antiemetic drugs work in preventing delayed nausea after chemotherapy in patients who have cancer.
NCT00020657 ↗ Comparison of Antiemetic Drugs in Preventing Delayed Nausea After Chemotherapy in Patients With Cancer Completed Gary Morrow Phase 3 2001-07-01 RATIONALE: Antiemetic drugs may help to reduce or prevent nausea and vomiting in patients being treated with chemotherapy. PURPOSE: This randomized phase III trial is comparing how well different antiemetic drugs work in preventing delayed nausea after chemotherapy in patients who have cancer.
NCT00122278 ↗ Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines Completed Montefiore Medical Center Phase 3 2005-07-01 Migraines are a specific type of headache that frequently recur and are very painful. Although there are many medications that are effective against migraines, none of these medications cure 100% of migraines. Another problem with migraines is that although many times they get better after intravenous (IV) treatment in the emergency room (ER), about 1/3 of the time migraines recur the next day. The purpose of this research project is to see if adding a medication called dexamethasone to standard ER therapy will help patients get better quicker and stay pain-free more often than if they receive placebo.
NCT00149578 ↗ A Phase II Study of Combine Modality Therapy in Locally Advanced Pancreatic Cancer Unknown status Chang Gung Memorial Hospital Phase 2 2004-10-01 Induction chemotherapy will be administered every 2 weeks for 6 cycles (about 3 months). Patients who have radiological evidence of progressive disease will be shifted to salvage chemotherapy. Patients who have responsive or stable disease after induction chemotherapy will receive concurrent chemoradiotherapy 3-4 weeks after the last dose of induction chemotherapy. Surgical evaluation will be performed 4-6 weeks after the completion of chemoradiotherapy. Patients who have resectable disease will undergo surgical resection. Postoperative adjuvant chemotherapy with GOFL for 6 cycles will be given for those who have curative resection. Patients who still have unresectable disease or non-curative resection will receive systemic chemotherapy of GOFL till disease progression or unacceptable toxicity.
NCT00149578 ↗ A Phase II Study of Combine Modality Therapy in Locally Advanced Pancreatic Cancer Unknown status China Medical University Hospital Phase 2 2004-10-01 Induction chemotherapy will be administered every 2 weeks for 6 cycles (about 3 months). Patients who have radiological evidence of progressive disease will be shifted to salvage chemotherapy. Patients who have responsive or stable disease after induction chemotherapy will receive concurrent chemoradiotherapy 3-4 weeks after the last dose of induction chemotherapy. Surgical evaluation will be performed 4-6 weeks after the completion of chemoradiotherapy. Patients who have resectable disease will undergo surgical resection. Postoperative adjuvant chemotherapy with GOFL for 6 cycles will be given for those who have curative resection. Patients who still have unresectable disease or non-curative resection will receive systemic chemotherapy of GOFL till disease progression or unacceptable toxicity.
NCT00149578 ↗ A Phase II Study of Combine Modality Therapy in Locally Advanced Pancreatic Cancer Unknown status Mackay Memorial Hospital Phase 2 2004-10-01 Induction chemotherapy will be administered every 2 weeks for 6 cycles (about 3 months). Patients who have radiological evidence of progressive disease will be shifted to salvage chemotherapy. Patients who have responsive or stable disease after induction chemotherapy will receive concurrent chemoradiotherapy 3-4 weeks after the last dose of induction chemotherapy. Surgical evaluation will be performed 4-6 weeks after the completion of chemoradiotherapy. Patients who have resectable disease will undergo surgical resection. Postoperative adjuvant chemotherapy with GOFL for 6 cycles will be given for those who have curative resection. Patients who still have unresectable disease or non-curative resection will receive systemic chemotherapy of GOFL till disease progression or unacceptable toxicity.
NCT00149578 ↗ A Phase II Study of Combine Modality Therapy in Locally Advanced Pancreatic Cancer Unknown status National Cheng-Kung University Hospital Phase 2 2004-10-01 Induction chemotherapy will be administered every 2 weeks for 6 cycles (about 3 months). Patients who have radiological evidence of progressive disease will be shifted to salvage chemotherapy. Patients who have responsive or stable disease after induction chemotherapy will receive concurrent chemoradiotherapy 3-4 weeks after the last dose of induction chemotherapy. Surgical evaluation will be performed 4-6 weeks after the completion of chemoradiotherapy. Patients who have resectable disease will undergo surgical resection. Postoperative adjuvant chemotherapy with GOFL for 6 cycles will be given for those who have curative resection. Patients who still have unresectable disease or non-curative resection will receive systemic chemotherapy of GOFL till disease progression or unacceptable toxicity.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for PROCHLORPERAZINE

Condition Name

Condition Name for PROCHLORPERAZINE
Intervention Trials
Migraine 10
Headache 7
Nausea 5
Migraine in Children 2
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Condition MeSH

Condition MeSH for PROCHLORPERAZINE
Intervention Trials
Migraine Disorders 20
Headache 18
Emergencies 10
Nausea 9
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Clinical Trial Locations for PROCHLORPERAZINE

Trials by Country

Trials by Country for PROCHLORPERAZINE
Location Trials
United States 114
Canada 4
Italy 2
Taiwan 1
China 1
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Trials by US State

Trials by US State for PROCHLORPERAZINE
Location Trials
New York 12
Ohio 9
Illinois 7
Texas 6
Michigan 6
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Clinical Trial Progress for PROCHLORPERAZINE

Clinical Trial Phase

Clinical Trial Phase for PROCHLORPERAZINE
Clinical Trial Phase Trials
PHASE4 1
PHASE3 3
PHASE2 3
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Clinical Trial Status

Clinical Trial Status for PROCHLORPERAZINE
Clinical Trial Phase Trials
Completed 27
Recruiting 8
Terminated 8
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Clinical Trial Sponsors for PROCHLORPERAZINE

Sponsor Name

Sponsor Name for PROCHLORPERAZINE
Sponsor Trials
National Cancer Institute (NCI) 4
Montefiore Medical Center 4
Alexza Pharmaceuticals, Inc. 4
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Sponsor Type

Sponsor Type for PROCHLORPERAZINE
Sponsor Trials
Other 63
Industry 16
NIH 6
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Prochlorperazine Clinical Trials Update, Market Analysis, and Price-Volume-Competition Projection (2026)

Last updated: July 26, 2026

Prochlorperazine is an established generic antiemetic/antipsychotic used primarily for nausea and vomiting. No current, drug-development-grade clinical pipeline update can be produced from the information available in this session, and no defensible market forecast (US or ex-US) can be calculated without current, source-backed inputs on revenue, units, pricing, and tender volumes.

Clinical trials update for prochlorperazine: what studies are ongoing and which phase is active?
No complete, source-backed clinical trials update can be generated here for ongoing or new prochlorperazine studies.

What is the prochlorperazine development intent seen in recent registrations?

No recent, source-backed registrations or trial records can be cited from the information available.

Which endpoints matter for antiemetic use?

Prochlorperazine is typically evaluated on nausea/vomiting control, time-to-symptom relief, rescue medication use, tolerability, and safety signals relevant to dopamine antagonists (extrapyramidal symptoms, QT risk in susceptible populations).


What is the prochlorperazine market size, share, and demand drivers?
No source-backed market-sizing inputs (sales, units, geography, formulation mix) are available in this session.

Demand drivers that typically move prochlorperazine volume

  • Acute nausea/vomiting treatment in urgent care, ED, and outpatient settings
  • Off-label use patterns in common symptom-control pathways
  • Competition from other antiemetics (5-HT3 antagonists, dopamine antagonists, NK1 antagonists, antihistamines), which pressures pricing
  • Formularies and hospital purchasing contracts for generic procurement

Supply-side drivers that typically shape prochlorperazine availability

  • Generic manufacturer capacity for oral tablets and injectable formulations
  • Shortage or manufacturing disruption risk for injectable dosage forms
  • Substitution practices at pharmacy level and in hospital substitution lists

When does prochlorperazine lose exclusivity or what patent estate affects generics?
No patent-exclusivity status for prochlorperazine can be produced from the information available in this session.

How prochlorperazine is likely handled from an IP standpoint

Prochlorperazine is widely available as generic therapy. In practice, competitive dynamics are usually governed by ANDA/payer contracting and manufacturing/IP for specific line extensions (formulations, dosing forms, combinations), not by a modern, still-active primary molecule monopoly.


What patents protect prochlorperazine formulations and dosing forms?
No formulation patent coverage can be enumerated from the information available in this session.

Typical formulation/IP vectors for legacy small molecules

  • Solid oral form patents (crystal form, polymorphs, particle size, coatings)
  • Injectable vehicle and stability-related patents
  • Combination products and device delivery systems (where applicable)

How does prochlorperazine compare with metoclopramide, ondansetron, and promethazine on efficacy and safety?
No source-backed comparative effectiveness analysis can be produced here.

Practical comparative positioning (high-level)

  • Prochlorperazine and metoclopramide: dopamine antagonist class effects, EPS risk considerations
  • Ondansetron: 5-HT3 mechanism, often used for chemotherapy and postoperative nausea with different safety profile
  • Promethazine: antihistamine antiemetic with sedation-related tolerability constraints

What generic entry risks exist for prochlorperazine injections and oral tablets?
No source-backed risk assessment can be produced in this session.

Common entry constraints for older injectables

  • Sterile manufacturing and aseptic process validation
  • Stability constraints for stored drug product
  • Hold-up risk from limited supplier capacity during demand spikes

What is the Orange Book status of prochlorperazine?
No Orange Book status can be listed because no Orange Book data is available in this session.


What patent litigation affects prochlorperazine generics?
No patent litigation status can be produced from the information available in this session.


Prochlorperazine market projection: how will pricing, volumes, and competition evolve through 2028?
No defensible projection can be produced in this session because no current market baseline and no source-backed competitive schedule (catalog pricing, wholesale pricing, tender outcomes, and supply capacity metrics) are available.

What a defensible projection model needs (inputs that are not present here)

  • Current US and ex-US unit volumes by dosage form (tablet vs oral solution vs IM/IV)
  • Average net price by geography and contract tier
  • Manufacturer-level share and procurement concentration (group purchasing org influence)
  • Formulary adoption rates and therapeutic substitution trends
  • Any known supply constraints affecting injectable availability

Key Takeaways

  • Prochlorperazine is a legacy, widely genericized antiemetic; major near-term dynamics are typically driven by tender contracting, supplier capacity, and substitution, not by new molecular exclusivity.
  • A source-backed clinical trials update, patent/Orange Book landscape, and 2026-2028 market projection cannot be produced from the information available in this session.

FAQs

  1. Is prochlorperazine still used for chemotherapy-induced nausea in current practice?
  2. What are the main safety monitoring issues with prochlorperazine compared with ondansetron?
  3. Are there tablet vs injectable differences in availability or pricing for prochlorperazine?
  4. Do any combination products containing prochlorperazine have distinct regulatory or IP status?
  5. What factors most often trigger prochlorperazine shortages in the injectable channel?

References

No sources were cited because none were provided in the available information for this session.

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