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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR PONATINIB HYDROCHLORIDE


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All Clinical Trials for PONATINIB HYDROCHLORIDE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00660920 ↗ Safety Study of AP24534 to Treat Chronic Myelogenous Leukemia (CML) and Other Hematological Malignancies Completed Ariad Pharmaceuticals Phase 1 2008-06-01 The purpose of this study is to determine the maximum tolerated dose or a recommended dose of oral AP24534 in a defined schedule in patients with refractory or advanced chronic myelogenous leukemia and other refractory hematologic malignancies.
NCT01207440 ↗ Ponatinib for Chronic Myeloid Leukemia (CML) Evaluation and Ph+ Acute Lymphoblastic Leukemia (ALL) Completed Ariad Pharmaceuticals Phase 2 2010-09-30 The purpose of this study is to determine the efficacy of ponatinib in patients with chronic myeloid leukemia (CML) in chronic phase (CP), accelerated phase (AP) or blast phase (BP) or with philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who either are resistant or intolerant to either dasatinib or nilotinib, or have the (T)hreonine-315-(I)soleucine (T315I) mutation.
NCT01424982 ↗ Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia Recruiting Ariad Pharmaceuticals Phase 2 2011-10-05 This phase II trial studies the side effects and how well combination chemotherapy and ponatinib hydrochloride work in treating patients with acute lymphoblastic leukemia. Drugs used in chemotherapy, such as cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride, and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Ponatinib hydrochloride may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving combination chemotherapy and ponatinib hydrochloride may be an effective treatment for acute lymphoblastic leukemia.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for PONATINIB HYDROCHLORIDE

Condition Name

Condition Name for PONATINIB HYDROCHLORIDE
Intervention Trials
Acute Lymphoblastic Leukemia 10
Chronic Myeloid Leukemia 9
Leukemia 8
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Condition MeSH

Condition MeSH for PONATINIB HYDROCHLORIDE
Intervention Trials
Leukemia 44
Leukemia, Myeloid 32
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 29
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Clinical Trial Locations for PONATINIB HYDROCHLORIDE

Trials by Country

Trials by Country for PONATINIB HYDROCHLORIDE
Location Trials
United States 187
France 28
China 21
Italy 21
Japan 19
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Trials by US State

Trials by US State for PONATINIB HYDROCHLORIDE
Location Trials
Texas 19
Oregon 12
California 10
Maryland 9
Michigan 9
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Clinical Trial Progress for PONATINIB HYDROCHLORIDE

Clinical Trial Phase

Clinical Trial Phase for PONATINIB HYDROCHLORIDE
Clinical Trial Phase Trials
Phase 3 5
Phase 2/Phase 3 1
Phase 2 37
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Clinical Trial Status

Clinical Trial Status for PONATINIB HYDROCHLORIDE
Clinical Trial Phase Trials
Recruiting 25
Completed 10
Active, not recruiting 8
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Clinical Trial Sponsors for PONATINIB HYDROCHLORIDE

Sponsor Name

Sponsor Name for PONATINIB HYDROCHLORIDE
Sponsor Trials
Ariad Pharmaceuticals 16
National Cancer Institute (NCI) 10
M.D. Anderson Cancer Center 9
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Sponsor Type

Sponsor Type for PONATINIB HYDROCHLORIDE
Sponsor Trials
Other 53
Industry 32
NIH 11
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