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Last Updated: March 28, 2024

CLINICAL TRIALS PROFILE FOR PERIOGARD


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All Clinical Trials for PERIOGARD

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01902446 ↗ Prehospital Ventilator-Associated Pneumonia Prevention Trial Completed Nicholas M Mohr 2013-07-01 Traumatic injury in rural America is a significant cause of morbidity and mortality, and the challenges of a rural trauma system can put patients at unique risk. Prolonged transport times to a trauma center, stopping for care at referring hospitals, and longer exposure to care-associated factors distinguish rural patients from their urban counterparts. Ventilator-associated pneumonia (VAP) is a significant risk in rural patients, increasing hospital stay, healthcare costs, and even mortality in the critically injured. The investigators propose a pilot study to test the hypothesis that a single dose of oral chlorhexidine gluconate (antiseptic) for trauma patients in the prehospital environment will decrease subsequent development of early VAP. Chlorhexidine is currently a standard therapy in intensive care units to prevent airway colonization and subsequent development of VAP. Demonstrating safety and effectiveness of prehospital infection control practices could significantly improve outcomes of traumatic injury in rural America.
NCT01902446 ↗ Prehospital Ventilator-Associated Pneumonia Prevention Trial Completed University of Iowa 2013-07-01 Traumatic injury in rural America is a significant cause of morbidity and mortality, and the challenges of a rural trauma system can put patients at unique risk. Prolonged transport times to a trauma center, stopping for care at referring hospitals, and longer exposure to care-associated factors distinguish rural patients from their urban counterparts. Ventilator-associated pneumonia (VAP) is a significant risk in rural patients, increasing hospital stay, healthcare costs, and even mortality in the critically injured. The investigators propose a pilot study to test the hypothesis that a single dose of oral chlorhexidine gluconate (antiseptic) for trauma patients in the prehospital environment will decrease subsequent development of early VAP. Chlorhexidine is currently a standard therapy in intensive care units to prevent airway colonization and subsequent development of VAP. Demonstrating safety and effectiveness of prehospital infection control practices could significantly improve outcomes of traumatic injury in rural America.
NCT02589067 ↗ Decolonization of the Oropharynx, an Important and Neglected Reservoir of S. Aureus Colonization Completed Thrasher Research Fund Phase 2 2015-10-01 The problem of interest is the high rate of recurrent SSTIs in children caused by S. aureus despite the use of systemic antibiotic treatment, due to difficulties in decolonization and the prevalence of antibiotic-resistant strains such as MRSA. This problem will be studied through a randomized, double-blind, placebo-controlled clinical trial of the use of a 0.12% clorhexidine gluconate (CHG) oral rinse in decolonizing S. aureus in the oropharynx in children 5-17 years old. CHG is an excellent candidate for use in children as its safety has been widely established, and it is readily commercially available. Eligible, consented subjects will be asked to participate in a baseline study visit in which swabs of their oropharynx and nares are obtained, and they are educated on the use of either CHG oral rinse or a placebo oral rinse containing saline. The subjects will be instructed to perform the oral rinse twice daily for seven days. Two follow-up visits will occur at 7 and 28 days post-baseline, where subjects' nares and oropharynx are again swabbed in order to ascertain short- and long-term decolonization of S. aureus. This procedure will serve to 1) determine the efficacy of a CHG oral rinse in decolonization of S. aureus, 2) investigate the safety, tolerability, and compliance of oropharyngeal decolonization among children and their caregivers, and 3) determine the genetic backgrounds of strains of S. aureus associated with continued colonization.
NCT02589067 ↗ Decolonization of the Oropharynx, an Important and Neglected Reservoir of S. Aureus Colonization Completed Los Angeles Biomedical Research Institute Phase 2 2015-10-01 The problem of interest is the high rate of recurrent SSTIs in children caused by S. aureus despite the use of systemic antibiotic treatment, due to difficulties in decolonization and the prevalence of antibiotic-resistant strains such as MRSA. This problem will be studied through a randomized, double-blind, placebo-controlled clinical trial of the use of a 0.12% clorhexidine gluconate (CHG) oral rinse in decolonizing S. aureus in the oropharynx in children 5-17 years old. CHG is an excellent candidate for use in children as its safety has been widely established, and it is readily commercially available. Eligible, consented subjects will be asked to participate in a baseline study visit in which swabs of their oropharynx and nares are obtained, and they are educated on the use of either CHG oral rinse or a placebo oral rinse containing saline. The subjects will be instructed to perform the oral rinse twice daily for seven days. Two follow-up visits will occur at 7 and 28 days post-baseline, where subjects' nares and oropharynx are again swabbed in order to ascertain short- and long-term decolonization of S. aureus. This procedure will serve to 1) determine the efficacy of a CHG oral rinse in decolonization of S. aureus, 2) investigate the safety, tolerability, and compliance of oropharyngeal decolonization among children and their caregivers, and 3) determine the genetic backgrounds of strains of S. aureus associated with continued colonization.
NCT02589067 ↗ Decolonization of the Oropharynx, an Important and Neglected Reservoir of S. Aureus Colonization Completed Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Phase 2 2015-10-01 The problem of interest is the high rate of recurrent SSTIs in children caused by S. aureus despite the use of systemic antibiotic treatment, due to difficulties in decolonization and the prevalence of antibiotic-resistant strains such as MRSA. This problem will be studied through a randomized, double-blind, placebo-controlled clinical trial of the use of a 0.12% clorhexidine gluconate (CHG) oral rinse in decolonizing S. aureus in the oropharynx in children 5-17 years old. CHG is an excellent candidate for use in children as its safety has been widely established, and it is readily commercially available. Eligible, consented subjects will be asked to participate in a baseline study visit in which swabs of their oropharynx and nares are obtained, and they are educated on the use of either CHG oral rinse or a placebo oral rinse containing saline. The subjects will be instructed to perform the oral rinse twice daily for seven days. Two follow-up visits will occur at 7 and 28 days post-baseline, where subjects' nares and oropharynx are again swabbed in order to ascertain short- and long-term decolonization of S. aureus. This procedure will serve to 1) determine the efficacy of a CHG oral rinse in decolonization of S. aureus, 2) investigate the safety, tolerability, and compliance of oropharyngeal decolonization among children and their caregivers, and 3) determine the genetic backgrounds of strains of S. aureus associated with continued colonization.
NCT02656251 ↗ Efficacy of Two Chlorhexidine Solutions to Control the Initial Subgingival Biofilm Formation Completed Federal University of Rio Grande do Sul Phase 3 2015-07-01 The aim of the study is to compare the effect of a suspension containing chlorhexidine and alcohol and another one containing clorhexidine with no alcohol in dynamic of the subgingival biofilm formation versus a Placebo suspension. The initial subgingival biofilm formation will be evaluated by means of Plaque Free Zone (PFZ).
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for PERIOGARD

Condition Name

Condition Name for PERIOGARD
Intervention Trials
Dental Plaque 2
COVID19 1
Gingivitis 1
Pneumonia, Ventilator-Associated 1
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Condition MeSH

Condition MeSH for PERIOGARD
Intervention Trials
Dental Plaque 2
Aggression 1
Infection 1
Gingivitis 1
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Clinical Trial Locations for PERIOGARD

Trials by Country

Trials by Country for PERIOGARD
Location Trials
Brazil 3
United States 3
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Trials by US State

Trials by US State for PERIOGARD
Location Trials
North Carolina 1
California 1
Iowa 1
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Clinical Trial Progress for PERIOGARD

Clinical Trial Phase

Clinical Trial Phase for PERIOGARD
Clinical Trial Phase Trials
Phase 4 1
Phase 3 1
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for PERIOGARD
Clinical Trial Phase Trials
Completed 5
Terminated 1
Unknown status 1
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Clinical Trial Sponsors for PERIOGARD

Sponsor Name

Sponsor Name for PERIOGARD
Sponsor Trials
University of North Carolina, Chapel Hill 1
University of Iowa 1
Thrasher Research Fund 1
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Sponsor Type

Sponsor Type for PERIOGARD
Sponsor Trials
Other 11
Industry 1
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