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Generated: December 18, 2018

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CLINICAL TRIALS PROFILE FOR PENTOXIFYLLINE

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Clinical Trials for PENTOXIFYLLINE

Trial ID Title Status Sponsor Phase Summary
NCT00000579 Acute Respiratory Distress Syndrome Clinical Network (ARDSNet) Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 The purposes of this study are to assess rapidly innovative treatment methods in patients with adult respiratory distress syndrome (ARDS) as well as those at risk of developing ARDS and to create a network of interactive Critical Care Treatment Groups (CCTGs) to establish and maintain the required infrastructure to perform multiple therapeutic trials that may involve investigational drugs, approved agents not currently used for treatment of ARDS, or treatments currently used but whose efficacy has not been well documented.
NCT00000646 Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS Completed Hoechst Marion Roussel Phase 1 To determine whether pentoxifylline lowers tumor necrosis factor (TNF) levels in AIDS patients. Pentoxifylline decreases tumor necrosis factor (TNF), and therefore should decrease such TNF-intensified events as cachexia, enhanced HIV expression, and inhibition of zidovudine (AZT) activity.
NCT00000646 Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 To determine whether pentoxifylline lowers tumor necrosis factor (TNF) levels in AIDS patients. Pentoxifylline decreases tumor necrosis factor (TNF), and therefore should decrease such TNF-intensified events as cachexia, enhanced HIV expression, and inhibition of zidovudine (AZT) activity.
NCT00001437 Trial of Pentoxifylline in Patients With Functional Disability Caused by Radiation-Induced Advanced Regional Fibrosis Completed National Cancer Institute (NCI) Phase 2 After initial assessment of their condition by specified clinical and laboratory parameters, each of the patients will be treated for 8 weeks at the standard pentoxifylline dose (400 mg po TID). Objective and subjective response parameters will be re-assessed at the end of the treatment and 8 weeks later for possible decay of response.
NCT00001877 Treatment of Pulmonary Sarcoidosis With Pentoxifylline Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 2 Sarcoidosis is a disease most commonly affecting the lungs, but it can also involve lymph nodes, skin, liver, spleen, eyes, bones, and glands. The cause of the disease is unknown. When it occurs it can produce an inflammatory reaction leading to irreversible organ damage and disability. In sarcoidosis granulomas can form in various organs (primarily lung) which can lead to its dysfunction. Granuloma is formed by clusters of inflammatory cells. The formation of these granulomas is influenced by the release of a substance called TNF-alpha (tumor necrosis factor alpha) which is found in some white blood cells. A drug known as pentoxifylline (POF) is known to markedly reduce the release of TNF-alpha. The standard medical treatment for sarcoidosis is steroid therapy. However, steroid therapy is associated with significant side effects and often must be stopped. Unfortunately, some of these patients can relapse when the steroid therapy is discontinued. Because of this, researchers are interested in finding alternative therapies for the treatment of sarcoidosis. This study will evaluate the effectiveness of giving POF to patients with sarcoidosis currently taking steroids. Researchers will compare the results between patients taking steroids with pentoxifylline and those patients taking steroids alone.
NCT00002091 An Evaluation of Pentoxifylline in HIV-Positive Persons With Symptomatic HIV Infection and a Karnofsky Score > 40 Percent and < 100 Percent Completed Community Research Initiative of New England N/A PRIMARY: To determine whether pentoxifylline changes the self-reported measures of quality of life status, using measures of scores from double-blinded drug withdrawal and drug restart periods. SECONDARY: To measure the changes in monthly CD4 counts, fasting serum triglyceride levels, and weight; to assess the safety of pentoxifylline in HIV-infected persons.
NCT00003407 Amifostine and High-Dose Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia or Chronic Myelogenous Leukemia Unknown status National Cancer Institute (NCI) Phase 2 RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Chemoprotective drugs, such as amifostine, may protect normal cells from the side effects of chemotherapy. PURPOSE: Phase II trial to study the effectiveness of amifostine and high-dose combination chemotherapy in treating patients with acute myeloid leukemia or chronic myelogenous leukemia.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for PENTOXIFYLLINE

Condition Name

Condition Name for PENTOXIFYLLINE
Intervention Trials
Alcoholic Hepatitis 6
HIV Infections 3
Nonalcoholic Steatohepatitis 3
Cardiovascular Diseases 3
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Condition MeSH

Condition MeSH for PENTOXIFYLLINE
Intervention Trials
Kidney Diseases 11
Hepatitis, Alcoholic 9
Hepatitis A 9
Hepatitis 9
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Clinical Trial Locations for PENTOXIFYLLINE

Trials by Country

Trials by Country for PENTOXIFYLLINE
Location Trials
United States 73
Taiwan 5
Egypt 4
Spain 4
India 4
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Trials by US State

Trials by US State for PENTOXIFYLLINE
Location Trials
Texas 7
Minnesota 5
Illinois 5
Ohio 5
Michigan 4
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Clinical Trial Progress for PENTOXIFYLLINE

Clinical Trial Phase

Clinical Trial Phase for PENTOXIFYLLINE
Clinical Trial Phase Trials
Phase 4 16
Phase 3 19
Phase 2/Phase 3 7
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Clinical Trial Status

Clinical Trial Status for PENTOXIFYLLINE
Clinical Trial Phase Trials
Completed 39
Recruiting 17
Unknown status 14
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Clinical Trial Sponsors for PENTOXIFYLLINE

Sponsor Name

Sponsor Name for PENTOXIFYLLINE
Sponsor Trials
National Heart, Lung, and Blood Institute (NHLBI) 5
National Taiwan University Hospital 5
National Cancer Institute (NCI) 3
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Sponsor Type

Sponsor Type for PENTOXIFYLLINE
Sponsor Trials
Other 131
NIH 14
Industry 7
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Serving hundreds of leading biopharmaceutical companies globally:

Fuji
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Johnson and Johnson
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McKesson
Medtronic
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Harvard Business School
Dow

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