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Generated: June 19, 2019

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CLINICAL TRIALS PROFILE FOR OXYMETAZOLINE HYDROCHLORIDE

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Clinical Trials for Oxymetazoline Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00487032 Differential Adrenoreceptor Mediated Tachyphylaxis and Upregulation Completed Brian J Lipworth Phase 4 The investigators wish to evaluate the onset of tolerance to nasal decongestants like oxymetazoline (available over the counter) and the mechanism of tolerance particularly with differential effects on alpha 1 and alpha 2 adrenoreceptors on the nose. The investigators will 'tease' out by using an alpha 1 blocker called Prazosin. The investigators hypothesize that alpha 1 receptors mediate arterial constriction and this will be captured by measuring nasal blood flow. The investigators also hypothesize that alpha 2 receptors mediate venous sinusoid constriction and this the investigators will capture by airflow parameters like Peak Nasal Inspiratory Flow, Rhinomanometry, Oscillometric indices etc.
NCT00520104 Determination of Drug Interactions of Certain Nasal Medications With Intranasal Ketamine Unknown status Javelin Pharmaceuticals Phase 1 This is an open label, single-center study to determine whether certain nasal medication interact with PMI-150 (intranasal ketamine) 30 mg in healthy adult volunteers and in patients with allergic rhinitis.
NCT00552110 Study of Mometasone Furoate Nasal Spray and Oxymetazoline Nasal Spray Given Together Once A Day To Treat Seasonal Allergic Rhinitis (P04500) Completed Quintiles, Inc. Phase 2 The primary objective of this study is to evaluate the efficacy of the combination of mometasone furoate nasal spray (MFNS) and oxymetazoline nasal spray (OXY) given together once a day in treating subjects with seasonal allergic rhinitis (SAR) in relieving symptoms including nasal congestion. The secondary objectives of this study are to evaluate the potential of the combination to produce tachyphylaxis and/or rebound congestion, and to evaluate the safety of the combination.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Oxymetazoline Hydrochloride

Condition Name

Condition Name for Oxymetazoline Hydrochloride
Intervention Trials
Allergic Rhinitis 6
Rosacea 3
Anesthesia 3
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Condition MeSH

Condition MeSH for Oxymetazoline Hydrochloride
Intervention Trials
Rhinitis 11
Rhinitis, Allergic 8
Rosacea 3
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Clinical Trial Locations for Oxymetazoline Hydrochloride

Trials by Country

Trials by Country for Oxymetazoline Hydrochloride
Location Trials
United States 18
United Kingdom 4
Bulgaria 2
Germany 1
Nepal 1
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Trials by US State

Trials by US State for Oxymetazoline Hydrochloride
Location Trials
Texas 3
Ohio 2
Pennsylvania 2
North Carolina 1
Tennessee 1
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Clinical Trial Progress for Oxymetazoline Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Oxymetazoline Hydrochloride
Clinical Trial Phase Trials
Phase 4 10
Phase 3 4
Phase 2 8
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Clinical Trial Status

Clinical Trial Status for Oxymetazoline Hydrochloride
Clinical Trial Phase Trials
Completed 19
Recruiting 5
Not yet recruiting 4
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Clinical Trial Sponsors for Oxymetazoline Hydrochloride

Sponsor Name

Sponsor Name for Oxymetazoline Hydrochloride
Sponsor Trials
St. Renatus, LLC 5
Rho, Inc. 5
Triligent International 3
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Sponsor Type

Sponsor Type for Oxymetazoline Hydrochloride
Sponsor Trials
Industry 34
Other 19
NIH 1
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