A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Pancreatic Cancer
Boston Biomedical, Inc
This is an open label, multi-center, multi-arm, dose-escalation study of BBI608 administered
in combination with Gemcitabine and nab-Paclitaxel, mFOLFIRINOX, FOLFIRI, or MM-398 with
5-FU and leucovorin.
Liposomal Irinotecan and Veliparib in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery
National Cancer Institute (NCI)
This phase I trial studies the side effects and best dose of veliparib when given together
with liposomal irinotecan in treating patients with solid tumors that have spread to other
parts of the body (metastatic) or cannot be removed by surgery. Liposomal irinotecan and
veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell
Study of Irinotecan Liposome Injection (ONIVYDE®) in Patients With Small Cell Lung Cancer
Not yet recruiting
This is an open-label phase 3 comparative study to assess the safety, tolerability, and
efficacy of irinotecan liposome injection compared to topotecan (IV) in patients with small
cell lung cancer who have progressed on or after platinum-based first-line therapy.
The study will be conducted in two parts:
1a. dose determination of irinotecan liposome injection
1b. preliminary safety and efficacy
2. a randomized, efficacy study of irinotecan liposome injection versus topotecan
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