The purpose of this study is to find the best treatment for Tourette's Syndrome (TS)-spectrum
obsessive-compulsive disorder (OCD), which includes symptoms of TS, e.g., repeated and
involuntary body movements (tics).
There are 2 parts to this study: In Part 1, patients are placed into 1 of 2 groups based on
type of OCD, determined by medical history and family member interviews. In Part 2, patients
are treated with fluvoxamine (FVX) for 8 weeks. If patients do not respond to FVX alone,
either haloperidol or an inactive placebo will be added to the FVX regimen; patients will
take this drug combination for 4 weeks. Patients will be monitored throughout the trial.
The purpose of this study is to find the best treatment for Tourette's Syndrome (TS)-spectrum
obsessive-compulsive disorder (OCD), which includes symptoms of TS, e.g., repeated and
involuntary body movements (tics).
There are 2 parts to this study: In Part 1, patients are placed into 1 of 2 groups based on
type of OCD, determined by medical history and family member interviews. In Part 2, patients
are treated with fluvoxamine (FVX) for 8 weeks. If patients do not respond to FVX alone,
either haloperidol or an inactive placebo will be added to the FVX regimen; patients will
take this drug combination for 4 weeks. Patients will be monitored throughout the trial.
This 3-year study will determine if the antipsychotic medications olanzapine (Zyprexa®) and
risperidone (Risperdal®) can help patients with first-episode schizophrenia.
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