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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR OSMITROL 15% IN WATER IN PLASTIC CONTAINER


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All Clinical Trials for OSMITROL 15% IN WATER IN PLASTIC CONTAINER

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00293475 ↗ Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma Active, not recruiting National Cancer Institute (NCI) Phase 1/Phase 2 2005-10-14 This phase I/II trial studies the side effects of methotrexate, mannitol, rituximab, and carboplatin and to see how well they work in treating patients with primary central nervous system lymphoma. Drugs used in chemotherapy, such as methotrexate and carboplatin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Osmotic blood-brain barrier disruption uses mannitol to open the blood vessels around the brain and allow cancer-killing substances to be carried directly to the brain. Monoclonal antibodies, such as rituximab, may block cancer growth in different ways by targeting certain cells. Giving methotrexate, mannitol, rituximab, and carboplatin together may be an effective treatment for primary central nervous system lymphoma.
NCT00293475 ↗ Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma Active, not recruiting Oregon Health and Science University Phase 1/Phase 2 2005-10-14 This phase I/II trial studies the side effects of methotrexate, mannitol, rituximab, and carboplatin and to see how well they work in treating patients with primary central nervous system lymphoma. Drugs used in chemotherapy, such as methotrexate and carboplatin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Osmotic blood-brain barrier disruption uses mannitol to open the blood vessels around the brain and allow cancer-killing substances to be carried directly to the brain. Monoclonal antibodies, such as rituximab, may block cancer growth in different ways by targeting certain cells. Giving methotrexate, mannitol, rituximab, and carboplatin together may be an effective treatment for primary central nervous system lymphoma.
NCT00293475 ↗ Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma Active, not recruiting OHSU Knight Cancer Institute Phase 1/Phase 2 2005-10-14 This phase I/II trial studies the side effects of methotrexate, mannitol, rituximab, and carboplatin and to see how well they work in treating patients with primary central nervous system lymphoma. Drugs used in chemotherapy, such as methotrexate and carboplatin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Osmotic blood-brain barrier disruption uses mannitol to open the blood vessels around the brain and allow cancer-killing substances to be carried directly to the brain. Monoclonal antibodies, such as rituximab, may block cancer growth in different ways by targeting certain cells. Giving methotrexate, mannitol, rituximab, and carboplatin together may be an effective treatment for primary central nervous system lymphoma.
NCT00303849 ↗ Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors Completed National Cancer Institute (NCI) Phase 1/Phase 2 2005-09-15 This phase I/II trial studies the side effects and best dose of melphalan when given together with carboplatin, etoposide phosphate, mannitol, and sodium thiosulfate and to see how well they work in treating patients with previously treated brain tumors. Drugs used in chemotherapy, such as melphalan, carboplatin, and etoposide phosphate, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing, or by stopping them from spreading. Osmotic blood-brain barrier disruption (BBBD) uses mannitol to open the blood vessels around the brain and allow cancer-killing substances to be carried directly to the brain. Sodium thiosulfate may help lessen or prevent hearing loss and toxicities in patients undergoing chemotherapy with carboplatin and BBBD. Giving carboplatin, melphalan, etoposide phosphate, mannitol, and sodium thiosulfate together may be an effective treatment for brain tumors.
NCT00303849 ↗ Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors Completed Oregon Health and Science University Phase 1/Phase 2 2005-09-15 This phase I/II trial studies the side effects and best dose of melphalan when given together with carboplatin, etoposide phosphate, mannitol, and sodium thiosulfate and to see how well they work in treating patients with previously treated brain tumors. Drugs used in chemotherapy, such as melphalan, carboplatin, and etoposide phosphate, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing, or by stopping them from spreading. Osmotic blood-brain barrier disruption (BBBD) uses mannitol to open the blood vessels around the brain and allow cancer-killing substances to be carried directly to the brain. Sodium thiosulfate may help lessen or prevent hearing loss and toxicities in patients undergoing chemotherapy with carboplatin and BBBD. Giving carboplatin, melphalan, etoposide phosphate, mannitol, and sodium thiosulfate together may be an effective treatment for brain tumors.
NCT00303849 ↗ Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors Completed OHSU Knight Cancer Institute Phase 1/Phase 2 2005-09-15 This phase I/II trial studies the side effects and best dose of melphalan when given together with carboplatin, etoposide phosphate, mannitol, and sodium thiosulfate and to see how well they work in treating patients with previously treated brain tumors. Drugs used in chemotherapy, such as melphalan, carboplatin, and etoposide phosphate, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing, or by stopping them from spreading. Osmotic blood-brain barrier disruption (BBBD) uses mannitol to open the blood vessels around the brain and allow cancer-killing substances to be carried directly to the brain. Sodium thiosulfate may help lessen or prevent hearing loss and toxicities in patients undergoing chemotherapy with carboplatin and BBBD. Giving carboplatin, melphalan, etoposide phosphate, mannitol, and sodium thiosulfate together may be an effective treatment for brain tumors.
NCT00983398 ↗ Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Active, not recruiting National Cancer Institute (NCI) Phase 1/Phase 2 2009-07-09 This phase I/II trial studies the side effects and best dose of melphalan when given together with carboplatin, mannitol, and sodium thiosulfate, and to see how well they work in treating patients with central nervous system (CNS) embryonal or germ cell tumors that is growing, spreading, or getting worse (progressive) or has come back (recurrent). Drugs used in chemotherapy, such as melphalan and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Osmotic blood-brain barrier disruption (BBBD) uses mannitol to open the blood vessels around the brain and allow cancer-killing substances to be carried directly to the brain. Sodium thiosulfate may help lessen or prevent hearing loss and toxicities in patients undergoing chemotherapy with carboplatin and BBBD. Giving melphalan together with carboplatin, mannitol, and sodium thiosulfate may be an effective treatment for recurrent or progressive CNS embryonal or germ cell tumors.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for OSMITROL 15% IN WATER IN PLASTIC CONTAINER

Condition Name

Condition Name for OSMITROL 15% IN WATER IN PLASTIC CONTAINER
Intervention Trials
Recurrent Adult Brain Neoplasm 2
Central Nervous System Lymphoma 1
Oligoastrocytoma 1
Recurrent Medulloblastoma 1
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Condition MeSH

Condition MeSH for OSMITROL 15% IN WATER IN PLASTIC CONTAINER
Intervention Trials
Brain Neoplasms 2
Neuroectodermal Tumors, Primitive 1
Inflammation 1
Neuroectodermal Tumors 1
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Clinical Trial Locations for OSMITROL 15% IN WATER IN PLASTIC CONTAINER

Trials by Country

Trials by Country for OSMITROL 15% IN WATER IN PLASTIC CONTAINER
Location Trials
United States 9
Australia 1
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Trials by US State

Trials by US State for OSMITROL 15% IN WATER IN PLASTIC CONTAINER
Location Trials
Oregon 3
Minnesota 3
Massachusetts 2
Ohio 1
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Clinical Trial Progress for OSMITROL 15% IN WATER IN PLASTIC CONTAINER

Clinical Trial Phase

Clinical Trial Phase for OSMITROL 15% IN WATER IN PLASTIC CONTAINER
Clinical Trial Phase Trials
Phase 1/Phase 2 4
Phase 1 1
N/A 1
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Clinical Trial Status

Clinical Trial Status for OSMITROL 15% IN WATER IN PLASTIC CONTAINER
Clinical Trial Phase Trials
Completed 3
Active, not recruiting 2
Withdrawn 1
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Clinical Trial Sponsors for OSMITROL 15% IN WATER IN PLASTIC CONTAINER

Sponsor Name

Sponsor Name for OSMITROL 15% IN WATER IN PLASTIC CONTAINER
Sponsor Trials
National Cancer Institute (NCI) 3
Oregon Health and Science University 3
OHSU Knight Cancer Institute 3
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Sponsor Type

Sponsor Type for OSMITROL 15% IN WATER IN PLASTIC CONTAINER
Sponsor Trials
Other 9
NIH 4
Industry 3
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