Determination of a Safe Dose of Optison in Pediatric Patients With Solid Tumors
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital is studying ways to make ultrasound images clearer -
to be able to see blood vessels, body structures, and tumors better. Ultrasound uses sound
waves to create pictures, allowing doctors and other medical professionals to "see" inside
Researchers are studying a contrast agent (like a dye) called Optison™. St. Jude Children's
Research Hospital researchers want to learn the best and safest dose of this ultrasound
Assessing Myocardial Blood Flow and Blood Flow Reserve by Transoesophageal Echocardiography (TEE)
University Hospital, Basel, Switzerland
Phase 1/Phase 2
Until today it was not possible to reliably assess the function of a new bypass, i.e., to
measure myocardial perfusion. Measuring intramyocardial blood flow directly after
revascularisation would greatly improve the assessment of graft function. With transthoracic
contrast echocardiography, myocardial perfusion can be reliably assessed, as it has been
shown in numerous studies. In the first part of the study the investigators will clarify
methodological aspects of contrast echocardiography. In the second part they will analyze
the validity of contrast TEE in the operating room.
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