A Study to Evaluate the Effects of Different Methods of Birth Control on the Drug Actions of Zidovudine (an Anti-HIV Drug) in HIV-Positive Women and to Compare Zidovudine Metabolism in Men and Women
National Institute of Allergy and Infectious Diseases (NIAID)
The purpose of this study is to look at the effects of different methods of birth control
(oral and injectable) on how the body absorbs, makes available, and removes zidovudine (ZDV).
This study will also evaluate the differences in men and women in how the body absorbs, makes
available, and removes ZDV.
Past research has shown that the effectiveness of ZDV as an anti-HIV drug might be decreased
in individuals who use certain methods of birth control. ZDV may also have different effects
in men compared to women.
Randomized Study of Oral Contraceptives or Hormone Replacement Therapy in Women With Systemic Lupus Erythematosus
University of Alabama at Birmingham
OBJECTIVES: I. Determine the effect of oral contraceptives containing low-dose synthetic
estrogens and progestins on disease activity in premenopausal women with inactive, stable, or
moderate systemic lupus erythematosus (SLE).
II. Determine the effect of hormone replacement therapy with conjugated estrogens and
progestins on disease activity in postmenopausal women with inactive, stable, or moderate
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