National Institute of Allergy and Infectious Diseases (NIAID)
Phase 3
1969-12-31
The purpose of this study is to see if nonoxynol-9 (N-9) gel used in the vagina can prevent
the spread of HIV.
Most of the people with HIV in the world today live in southern Africa. Because this
population is not likely to use condoms, an HIV-prevention method that women can control is
needed. N-9 used in the vagina may help prevent the spread of HIV and other sexually
transmitted diseases.
A Study of the Effects of Advantage 24 on the Rectum
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
Phase 1
1969-12-31
The purpose of this study is to see if it is safe and acceptable for homosexual male couples,
where both partners have the same HIV status, to use Advantage 24 during anal intercourse.
Advantage 24 is a spermicide (a chemical that kills sperm).
Much research and development is being done with chemicals that can be controlled by the
receptive partner to prevent the spread of HIV and other sexually transmitted diseases
(STDs). Advantage 24 currently is used in the vagina as a form of birth control. The safety
of Advantage 24 is particularly important for HIV-positive men because they have a greater
chance of serious reaction to Advantage 24 due to other HIV-related conditions.
National Institute of Allergy and Infectious Diseases (NIAID)
Phase 1
1969-12-31
The purpose of this study is to find out if there are any bad effects when BufferGel or PRO
2000/5 Gel are applied to the penis of HIV-infected men.
Microbicides are products to be used by women for placing into the vagina to prevent passing
HIV from 1 person to another during sex. Studies have shown 2 investigational microbicides,
BufferGel and PRO 2000/5 Gel, to be safe and acceptable for women and HIV-negative men. It is
important to see if the side effects of these products are the same in men as those in women
and to see if there is any difference in the side effects between circumcised and
uncircumcised men.
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